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Immunological mechanisms of the antitumor effects of supplemental oxygenation.
Hatfield SM, Kjaergaard J, Lukashev D, Schreiber TH, Belikoff B, Abbott R, Sethumadhavan S, Philbrook P, Ko K, Cannici R, Thayer M, Rodig S, Kutok JL, Jackson EK, Karger B, Podack ER, Ohta A, Sitkovsky MV. Hatfield SM, et al. Among authors: ohta a. Sci Transl Med. 2015 Mar 4;7(277):277ra30. doi: 10.1126/scitranslmed.aaa1260. Sci Transl Med. 2015. PMID: 25739764 Free PMC article.
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection.
Hatfield SM, Kjaergaard J, Lukashev D, Belikoff B, Schreiber TH, Sethumadhavan S, Abbott R, Philbrook P, Thayer M, Shujia D, Rodig S, Kutok JL, Ren J, Ohta A, Podack ER, Karger B, Jackson EK, Sitkovsky M. Hatfield SM, et al. Among authors: ohta a. J Mol Med (Berl). 2014 Dec;92(12):1283-92. doi: 10.1007/s00109-014-1189-3. Epub 2014 Aug 15. J Mol Med (Berl). 2014. PMID: 25120128 Free PMC article.
From "Hellstrom Paradox" to anti-adenosinergic cancer immunotherapy.
Lukashev D, Sitkovsky M, Ohta A. Lukashev D, et al. Among authors: ohta a. Purinergic Signal. 2007 Mar;3(1-2):129-34. doi: 10.1007/s11302-006-9044-9. Epub 2007 Jan 24. Purinergic Signal. 2007. PMID: 18404426 Free PMC article.
This may be now possible because of the recent demonstration that genetic deletion of immunosuppressive A2A and A2B adenosine receptors (A2AR and A2BR) or their pharmacological inactivation can prevent the inhibition of anti-tumor T cells by the hypoxic tumor microenvironment and …
This may be now possible because of the recent demonstration that genetic deletion of immunosuppressive A2A and A2B adenosine receptors (A2A …
The adenosinergic immunomodulatory drugs.
Ohta A, Sitkovsky M. Ohta A, et al. Curr Opin Pharmacol. 2009 Aug;9(4):501-6. doi: 10.1016/j.coph.2009.05.005. Epub 2009 Jun 17. Curr Opin Pharmacol. 2009. PMID: 19539527 Free PMC article. Review.
908 results