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KIM-1-mediated phagocytosis reduces acute injury to the kidney.
Yang L, Brooks CR, Xiao S, Sabbisetti V, Yeung MY, Hsiao LL, Ichimura T, Kuchroo V, Bonventre JV. Yang L, et al. Among authors: kuchroo v. J Clin Invest. 2015 Apr;125(4):1620-36. doi: 10.1172/JCI75417. Epub 2015 Mar 9. J Clin Invest. 2015. PMID: 25751064 Free PMC article.
Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4+ and CD8+ T cells.
Golden-Mason L, Palmer BE, Kassam N, Townshend-Bulson L, Livingston S, McMahon BJ, Castelblanco N, Kuchroo V, Gretch DR, Rosen HR. Golden-Mason L, et al. Among authors: kuchroo v. J Virol. 2009 Sep;83(18):9122-30. doi: 10.1128/JVI.00639-09. Epub 2009 Jul 8. J Virol. 2009. PMID: 19587053 Free PMC article.
CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1.
Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher IF, Sander C, Kirkwood JM, Olive D, Kuchroo V, Zarour HM. Fourcade J, et al. Among authors: kuchroo v. Cancer Res. 2012 Feb 15;72(4):887-96. doi: 10.1158/0008-5472.CAN-11-2637. Epub 2011 Dec 28. Cancer Res. 2012. PMID: 22205715 Free PMC article.
TIMs: central regulators of immune responses.
Hafler DA, Kuchroo V. Hafler DA, et al. Among authors: kuchroo v. J Exp Med. 2008 Nov 24;205(12):2699-701. doi: 10.1084/jem.20082429. Epub 2008 Nov 17. J Exp Med. 2008. PMID: 19015312 Free PMC article.
The TIGIT/CD226 axis regulates human T cell function.
Lozano E, Dominguez-Villar M, Kuchroo V, Hafler DA. Lozano E, et al. Among authors: kuchroo v. J Immunol. 2012 Apr 15;188(8):3869-75. doi: 10.4049/jimmunol.1103627. Epub 2012 Mar 16. J Immunol. 2012. PMID: 22427644 Free PMC article.
Galectin-9 suppresses the generation of Th17, promotes the induction of regulatory T cells, and regulates experimental autoimmune arthritis.
Seki M, Oomizu S, Sakata KM, Sakata A, Arikawa T, Watanabe K, Ito K, Takeshita K, Niki T, Saita N, Nishi N, Yamauchi A, Katoh S, Matsukawa A, Kuchroo V, Hirashima M. Seki M, et al. Among authors: kuchroo v. Clin Immunol. 2008 Apr;127(1):78-88. doi: 10.1016/j.clim.2008.01.006. Epub 2008 Feb 20. Clin Immunol. 2008. PMID: 18282810
467 results