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Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.
Wirsdörfer F, de Leve S, Cappuccini F, Eldh T, Meyer AV, Gau E, Thompson LF, Chen NY, Karmouty-Quintana H, Fischer U, Kasper M, Klein D, Ritchey JW, Blackburn MR, Westendorf AM, Stuschke M, Jendrossek V. Wirsdörfer F, et al. Cancer Res. 2016 May 15;76(10):3045-56. doi: 10.1158/0008-5472.CAN-15-2310. Epub 2016 Feb 26. Cancer Res. 2016. PMID: 26921334 Free PMC article.
Mesenchymal Stem Cell Therapy Protects Lungs from Radiation-Induced Endothelial Cell Loss by Restoring Superoxide Dismutase 1 Expression.
Klein D, Steens J, Wiesemann A, Schulz F, Kaschani F, Röck K, Yamaguchi M, Wirsdörfer F, Kaiser M, Fischer JW, Stuschke M, Jendrossek V. Klein D, et al. Among authors: wirsdorfer f. Antioxid Redox Signal. 2017 Apr 10;26(11):563-582. doi: 10.1089/ars.2016.6748. Epub 2016 Nov 14. Antioxid Redox Signal. 2017. PMID: 27572073 Free PMC article.
Loss of CD73 prevents accumulation of alternatively activated macrophages and the formation of prefibrotic macrophage clusters in irradiated lungs.
de Leve S, Wirsdörfer F, Cappuccini F, Schütze A, Meyer AV, Röck K, Thompson LF, Fischer JW, Stuschke M, Jendrossek V. de Leve S, et al. Among authors: wirsdorfer f. FASEB J. 2017 Jul;31(7):2869-2880. doi: 10.1096/fj.201601228R. Epub 2017 Mar 21. FASEB J. 2017. PMID: 28325757 Free PMC article.
We speculate that accumulation of alternatively activated macrophages in organized clusters represents the origins of fibrotic foci after WTI and is promoted by a cross-talk between HA, CD73/adenosine signaling, and other profibrotic mediators.-De Leve, S., Wirsdorfer, …
We speculate that accumulation of alternatively activated macrophages in organized clusters represents the origins of fibrotic foci after WT …
23 results