P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse.
Iyengar S, Clear A, Bödör C, Maharaj L, Lee A, Calaminici M, Matthews J, Iqbal S, Auer R, Gribben J, Joel S.
Iyengar S, et al. Among authors: clear a.
Blood. 2013 Mar 21;121(12):2274-84. doi: 10.1182/blood-2012-10-460832. Epub 2013 Jan 22.
Blood. 2013.
PMID: 23341541
Free PMC article.
We found that a high PIK3CA/PIK3CD ratio identified a subset of primary MCLs resistant to GS-1101 and this ratio increased significantly with relapse. These findings support the use of dual p110alpha/p110delta inhibitors in MCL and suggest a role for p110alph …
We found that a high PIK3CA/PIK3CD ratio identified a subset of primary MCLs resistant to GS-1101 and this ratio increased sig …