Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum.
Gao X, Gao S, Guan Y, Huang L, Huang J, Lin L, Liu Y, Zhao H, Huang B, Yuan T, Liu Y, Liang D, Zhang Y, Ma X, Li L, Li J, Zhou D, Shi D, Xu L, Chen YH.
Gao X, et al. Among authors: lin l.
FASEB J. 2019 May 1;33(5):6197-6208. doi: 10.1096/fj.201801464R. Epub 2019 Feb 13.
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PMID: 30758987
Thus, our data indicated that TLR3 directly regulates I(to) channel protein dynamics to maintain cardiac repolarization, which may implicate a new molecular surveillance system for cardiac electrophysiological homeostasis.-Gao, X., Gao, S., Guan, Y., Huang, L., Huang, J., …
Thus, our data indicated that TLR3 directly regulates I(to) channel protein dynamics to maintain cardiac repolarization, which may implicate …