Zhu Y - Search Results

1

Neonatal Systemic AAV Induces Tolerance to CNS Gene Therapy in MPS I Dogs and Nonhuman Primates.

Hinderer C, Bell P, Louboutin JP, Zhu Y, Yu H, Lin G, Choa R, Gurda BL, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Tarantal AF, Casal ML, Haskins ME, Wilson JM. Hinderer C, et al. Among authors: zhu y. Mol Ther. 2015 Aug;23(8):1298-1307. doi: 10.1038/mt.2015.99. Epub 2015 May 29. Mol Ther. 2015. PMID: 26022732 Free PMC article.

2

Inverse zonation of hepatocyte transduction with AAV vectors between mice and non-human primates.

Bell P, Wang L, Gao G, Haskins ME, Tarantal AF, McCarter RJ, Zhu Y, Yu H, Wilson JM. Bell P, et al. Among authors: zhu y. Mol Genet Metab. 2011 Nov;104(3):395-403. doi: 10.1016/j.ymgme.2011.06.002. Epub 2011 Jun 12. Mol Genet Metab. 2011. PMID: 21778099 Free PMC article.

3

CpG-depleted adeno-associated virus vectors evade immune detection.

Faust SM, Bell P, Cutler BJ, Ashley SN, Zhu Y, Rabinowitz JE, Wilson JM. Faust SM, et al. Among authors: zhu y. J Clin Invest. 2013 Jul;123(7):2994-3001. doi: 10.1172/JCI68205. Epub 2013 Jun 17. J Clin Invest. 2013. PMID: 23778142 Free PMC article.

4

The role of apoptosis in immune hyporesponsiveness following AAV8 liver gene transfer.

Faust SM, Bell P, Zhu Y, Sanmiguel J, Wilson JM. Faust SM, et al. Among authors: zhu y. Mol Ther. 2013 Dec;21(12):2227-35. doi: 10.1038/mt.2013.94. Epub 2013 Oct 15. Mol Ther. 2013. PMID: 24126962 Free PMC article.

5

Intrathecal gene therapy corrects CNS pathology in a feline model of mucopolysaccharidosis I.

Hinderer C, Bell P, Gurda BL, Wang Q, Louboutin JP, Zhu Y, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Haskins ME, Wilson JM. Hinderer C, et al. Among authors: zhu y. Mol Ther. 2014 Dec;22(12):2018-2027. doi: 10.1038/mt.2014.135. Epub 2014 Jul 16. Mol Ther. 2014. PMID: 25027660 Free PMC article.

6

Liver-directed gene therapy corrects cardiovascular lesions in feline mucopolysaccharidosis type I.

Hinderer C, Bell P, Gurda BL, Wang Q, Louboutin JP, Zhu Y, Bagel J, O'Donnell P, Sikora T, Ruane T, Wang P, Haskins ME, Wilson JM. Hinderer C, et al. Among authors: zhu y. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14894-9. doi: 10.1073/pnas.1413645111. Epub 2014 Sep 29. Proc Natl Acad Sci U S A. 2014. PMID: 25267637 Free PMC article.

7

Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII.

Gurda BL, De Guilhem De Lataillade A, Bell P, Zhu Y, Yu H, Wang P, Bagel J, Vite CH, Sikora T, Hinderer C, Calcedo R, Yox AD, Steet RA, Ruane T, O'Donnell P, Gao G, Wilson JM, Casal M, Ponder KP, Haskins ME. Gurda BL, et al. Among authors: zhu y. Mol Ther. 2016 Feb;24(2):206-216. doi: 10.1038/mt.2015.189. Epub 2015 Oct 8. Mol Ther. 2016. PMID: 26447927 Free PMC article.

8

Neonatal tolerance induction enables accurate evaluation of gene therapy for MPS I in a canine model.

Hinderer C, Bell P, Louboutin JP, Katz N, Zhu Y, Lin G, Choa R, Bagel J, O'Donnell P, Fitzgerald CA, Langan T, Wang P, Casal ML, Haskins ME, Wilson JM. Hinderer C, et al. Among authors: zhu y. Mol Genet Metab. 2016 Sep;119(1-2):124-30. doi: 10.1016/j.ymgme.2016.06.006. Epub 2016 Jun 8. Mol Genet Metab. 2016. PMID: 27386755 Free PMC article.

9

Effects of Self-Complementarity, Codon Optimization, Transgene, and Dose on Liver Transduction with AAV8.

Bell P, Wang L, Chen SJ, Yu H, Zhu Y, Nayal M, He Z, White J, Lebel-Hagan D, Wilson JM. Bell P, et al. Among authors: zhu y. Hum Gene Ther Methods. 2016 Dec;27(6):228-237. doi: 10.1089/hgtb.2016.039. Hum Gene Ther Methods. 2016. PMID: 27903094 Free PMC article.

10

Evaluation of Intrathecal Routes of Administration for Adeno-Associated Viral Vectors in Large Animals.

Hinderer C, Bell P, Katz N, Vite CH, Louboutin JP, Bote E, Yu H, Zhu Y, Casal ML, Bagel J, O'Donnell P, Wang P, Haskins ME, Goode T, Wilson JM. Hinderer C, et al. Among authors: zhu y. Hum Gene Ther. 2018 Jan;29(1):15-24. doi: 10.1089/hum.2017.026. Epub 2017 Oct 3. Hum Gene Ther. 2018. PMID: 28806897 Free PMC article.

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