He B - Search Results

1

Characterization of ADME properties of [(14)C]asunaprevir (BMS-650032) in humans.

Gong J, Eley T, He B, Arora V, Philip T, Jiang H, Easter J, Humphreys WG, Iyer RA, Li W. Gong J, et al. Among authors: he b. Xenobiotica. 2016;46(1):52-64. doi: 10.3109/00498254.2015.1048487. Epub 2015 Jul 7. Xenobiotica. 2016. PMID: 26153443 Clinical Trial.

2

In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.

Gan J, Ruan Q, He B, Zhu M, Shyu WC, Humphreys WG. Gan J, et al. Among authors: he b. Chem Res Toxicol. 2009 Apr;22(4):690-8. doi: 10.1021/tx800368n. Chem Res Toxicol. 2009. PMID: 19253935

3

Randomized study of asunaprevir plus pegylated interferon-α and ribavirin for previously untreated genotype 1 chronic hepatitis C.

Bronowicki JP, Pol S, Thuluvath PJ, Larrey D, Martorell CT, Rustgi VK, Morris DW, Younes Z, Fried MW, Bourlière M, Hézode C, Reddy KR, Massoud O, Abrams GA, Ratziu V, He B, Eley T, Ahmad A, Cohen D, Hindes R, McPhee F, Reilly B, Mendez P, Hughes E. Bronowicki JP, et al. Among authors: he b. Antivir Ther. 2013;18(7):885-93. doi: 10.3851/IMP2660. Epub 2013 Jun 26. Antivir Ther. 2013. PMID: 23804631 Clinical Trial.

4

The effect of hepatic impairment on the pharmacokinetics of asunaprevir, an HCV NS3 protease inhibitor.

Eley T, He B, Chang I, Colston E, Child M, Bedford W, Kandoussi H, Pasquinelli C, Marbury TC, Bertz RJ. Eley T, et al. Among authors: he b. Antivir Ther. 2015;20(1):29-37. doi: 10.3851/IMP2773. Epub 2014 Apr 7. Antivir Ther. 2015. PMID: 24704773 Clinical Trial.

5

Randomized trial of asunaprevir plus peginterferon alfa and ribavirin for previously untreated genotype 1 or 4 chronic hepatitis C.

Bronowicki JP, Ratziu V, Gadano A, Thuluvath PJ, Bessone F, Martorell CT, Pol S, Terg R, Younes Z, He B, Eley T, Cohen D, Yu F, Hernandez D, McPhee F, Mendez P, Hughes E. Bronowicki JP, et al. Among authors: he b. J Hepatol. 2014 Dec;61(6):1220-7. doi: 10.1016/j.jhep.2014.07.011. Epub 2014 Jul 16. J Hepatol. 2014. PMID: 25038486 Clinical Trial.

6

The pharmacokinetics of daclatasvir and asunaprevir administered in combination in studies in healthy subjects and patients infected with hepatitis C virus.

Eley T, Sevinsky H, Huang SP, He B, Zhu K, Kandoussi H, Gardiner D, Grasela DM, Bertz R, Bifano M. Eley T, et al. Among authors: he b. Clin Drug Investig. 2014 Sep;34(9):661-71. doi: 10.1007/s40261-014-0219-9. Clin Drug Investig. 2014. PMID: 25117173 Clinical Trial.

7

Organic anion transporting polypeptide-mediated transport of, and inhibition by, asunaprevir, an inhibitor of hepatitis C virus NS3 protease.

Eley T, Han YH, Huang SP, He B, Li W, Bedford W, Stonier M, Gardiner D, Sims K, Rodrigues AD, Bertz RJ. Eley T, et al. Among authors: he b. Clin Pharmacol Ther. 2015 Feb;97(2):159-66. doi: 10.1002/cpt.4. Epub 2014 Dec 20. Clin Pharmacol Ther. 2015. PMID: 25670521 Clinical Trial.

8

Multiplexed LC-MS/MS method for the simultaneous quantitation of three novel hepatitis C antivirals, daclatasvir, asunaprevir, and beclabuvir in human plasma.

Jiang H, Kandoussi H, Zeng J, Wang J, Demers R, Eley T, He B, Burrell R, Easter J, Kadiyala P, Pursley J, Cojocaru L, Baker C, Ryan J, Aubry AF, Arnold ME. Jiang H, et al. Among authors: he b. J Pharm Biomed Anal. 2015 Mar 25;107:409-18. doi: 10.1016/j.jpba.2015.01.027. Epub 2015 Jan 20. J Pharm Biomed Anal. 2015. PMID: 25676854

9

A highly sensitive and selective LC-MS/MS method to quantify asunaprevir, an HCV NS3 protease inhibitor, in human plasma in support of pharmacokinetic studies.

Kandoussi H, Jiang H, Zeng J, Zheng N, Kadiyala P, Eley T, He B, Garimella T, Demers R, Cojocaru L, Aubry AF, Arnold ME. Kandoussi H, et al. Among authors: he b. J Pharm Biomed Anal. 2016 Feb 5;119:145-51. doi: 10.1016/j.jpba.2015.11.028. Epub 2015 Nov 23. J Pharm Biomed Anal. 2016. PMID: 26683987

10

Pharmacokinetics of the NS3 Protease Inhibitor, Asunaprevir (ASV, BMS-650032), in Phase I Studies in Subjects With or Without Chronic Hepatitis C.

Eley T, He B, Huang SP, Li W, Pasquinelli C, Rodrigues AD, Grasela DM, Bertz RJ. Eley T, et al. Among authors: he b. Clin Pharmacol Drug Dev. 2013 Oct;2(4):316-27. doi: 10.1002/cpdd.52. Epub 2013 Aug 16. Clin Pharmacol Drug Dev. 2013. PMID: 27121936

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