Humphreys WG - Search Results

1

Characterization of ADME properties of [(14)C]asunaprevir (BMS-650032) in humans.

Gong J, Eley T, He B, Arora V, Philip T, Jiang H, Easter J, Humphreys WG, Iyer RA, Li W. Gong J, et al. Among authors: humphreys wg. Xenobiotica. 2016;46(1):52-64. doi: 10.3109/00498254.2015.1048487. Epub 2015 Jul 7. Xenobiotica. 2016. PMID: 26153443 Clinical Trial.

2

Oxidative activation of acylguanidine prodrugs: intestinal presystemic activation in rats limits absorption and can be inhibited by co-administration of ketoconazole.

Humphreys WG, Obermeier MT, Chong S, Kimball SD, Das J, Chen P, Moquin R, Han WC, Gedamke R, White RE, Morrison RA. Humphreys WG, et al. Xenobiotica. 2003 Jan;33(1):93-106. doi: 10.1080/0049825021000012592. Xenobiotica. 2003. PMID: 12519697

3

Application of structure-metabolism relationships in the identification of a selective endothelin A antagonist, BMS-193884, with favourable pharmacokinetic properties.

Humphreys WG, Obermeier MT, Barrish JC, Chong S, Marino AM, Murugesan N, Wang-Iverson D, Morrison RA. Humphreys WG, et al. Xenobiotica. 2003 Nov;33(11):1109-23. doi: 10.1080/00498250310001609147. Xenobiotica. 2003. PMID: 14660175

4

Glucuronidation as a major metabolic clearance pathway of 14c-labeled muraglitazar in humans: metabolic profiles in subjects with or without bile collection.

Wang L, Zhang D, Swaminathan A, Xue Y, Cheng PT, Wu S, Mosqueda-Garcia R, Aurang C, Everett DW, Humphreys WG. Wang L, et al. Among authors: humphreys wg. Drug Metab Dispos. 2006 Mar;34(3):427-39. doi: 10.1124/dmd.105.007617. Epub 2005 Dec 28. Drug Metab Dispos. 2006. PMID: 16381667

5

Biotransformation of carbon-14-labeled muraglitazar in male mice: interspecies difference in metabolic pathways leading to unique metabolites.

Li W, Zhang D, Wang L, Zhang H, Cheng PT, Zhang D, Everett DW, Humphreys WG. Li W, et al. Among authors: humphreys wg. Drug Metab Dispos. 2006 May;34(5):807-20. doi: 10.1124/dmd.105.007856. Epub 2006 Feb 7. Drug Metab Dispos. 2006. PMID: 16467134

6

Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling.

Zhang D, Wang L, Raghavan N, Zhang H, Li W, Cheng PT, Yao M, Zhang L, Zhu M, Bonacorsi S, Yeola S, Mitroka J, Hariharan N, Hosagrahara V, Chandrasena G, Shyu WC, Humphreys WG. Zhang D, et al. Among authors: humphreys wg. Drug Metab Dispos. 2007 Jan;35(1):150-67. doi: 10.1124/dmd.106.012450. Epub 2006 Oct 24. Drug Metab Dispos. 2007. PMID: 17062777 Clinical Trial.

7

Pharmacokinetics of muraglitazar (BMS-298585), a dual peroxisome proliferator-activated receptors (PPAR) alpha and gamma activator, in mice, rats, dogs, and monkeys.

Hosagrahara VP, Chandrasena G, Chang SY, Koplowitz B, Hariharan N, Cheng PT, Humphreys WG. Hosagrahara VP, et al. Among authors: humphreys wg. Xenobiotica. 2006 Dec;36(12):1227-38. doi: 10.1080/00498250600829378. Xenobiotica. 2006. PMID: 17162469

8

Reduction of site-specific CYP3A-mediated metabolism for dual angiotensin and endothelin receptor antagonists in various in vitro systems and in cynomolgus monkeys.

Zhang H, Zhang D, Li W, Yao M, D'Arienzo C, Li YX, Ewing WR, Gu Z, Zhu Y, Murugesan N, Shyu WC, Humphreys WG. Zhang H, et al. Among authors: humphreys wg. Drug Metab Dispos. 2007 May;35(5):795-805. doi: 10.1124/dmd.106.012781. Epub 2007 Feb 15. Drug Metab Dispos. 2007. PMID: 17303626

9

Metabolite generation via microbial biotransformations with Actinomycetes: rapid screening for active strains and biosynthesis of important human metabolites of two development-stage compounds, 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101) and dasatinib.

Li W, Josephs JL, Skiles GL, Humphreys WG. Li W, et al. Among authors: humphreys wg. Drug Metab Dispos. 2008 Apr;36(4):721-30. doi: 10.1124/dmd.107.019570. Epub 2008 Jan 28. Drug Metab Dispos. 2008. PMID: 18227141

10

Metabolism and disposition of dasatinib after oral administration to humans.

Christopher LJ, Cui D, Wu C, Luo R, Manning JA, Bonacorsi SJ, Lago M, Allentoff A, Lee FY, McCann B, Galbraith S, Reitberg DP, He K, Barros A Jr, Blackwood-Chirchir A, Humphreys WG, Iyer RA. Christopher LJ, et al. Among authors: humphreys wg. Drug Metab Dispos. 2008 Jul;36(7):1357-64. doi: 10.1124/dmd.107.018267. Epub 2008 Apr 17. Drug Metab Dispos. 2008. PMID: 18420784

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