Worthington J - Search Results

1

Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo.

Nesbitt H, Browne G, O'Donovan KM, Byrne NM, Worthington J, McKeown SR, McKenna DJ. Nesbitt H, et al. Among authors: worthington j. J Cell Physiol. 2016 Feb;231(2):473-82. doi: 10.1002/jcp.25093. J Cell Physiol. 2016. PMID: 26189652

2

Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: informed scheduling of the bioreductive drug AQ4N improves treatment response.

Ming L, Byrne NM, Camac SN, Mitchell CA, Ward C, Waugh DJ, McKeown SR, Worthington J. Ming L, et al. Among authors: worthington j. Int J Cancer. 2013 Mar 15;132(6):1323-32. doi: 10.1002/ijc.27796. Epub 2012 Nov 23. Int J Cancer. 2013. PMID: 22915157

3

Targeting Hypoxic Prostate Tumors Using the Novel Hypoxia-Activated Prodrug OCT1002 Inhibits Expression of Genes Associated with Malignant Progression.

Nesbitt H, Byrne NM, Williams SN, Ming L, Worthington J, Errington RJ, Patterson LH, Smith PJ, McKeown SR, McKenna DJ. Nesbitt H, et al. Among authors: worthington j. Clin Cancer Res. 2017 Apr 1;23(7):1797-1808. doi: 10.1158/1078-0432.CCR-16-1361. Epub 2016 Oct 3. Clin Cancer Res. 2017. PMID: 27697998

4

Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistance.

Browne G, Nesbitt H, Ming L, Stein GS, Lian JB, McKeown SR, Worthington J. Browne G, et al. Among authors: worthington j. Br J Cancer. 2012 Nov 6;107(10):1714-21. doi: 10.1038/bjc.2012.455. Epub 2012 Oct 16. Br J Cancer. 2012. PMID: 23073173 Free PMC article.

5

Androgen deprivation in LNCaP prostate tumour xenografts induces vascular changes and hypoxic stress, resulting in promotion of epithelial-to-mesenchymal transition.

Byrne NM, Nesbitt H, Ming L, McKeown SR, Worthington J, McKenna DJ. Byrne NM, et al. Among authors: worthington j. Br J Cancer. 2016 Mar 15;114(6):659-68. doi: 10.1038/bjc.2016.29. Epub 2016 Mar 8. Br J Cancer. 2016. PMID: 26954717 Free PMC article.

6

Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotype.

Butterworth KT, McCarthy HO, Devlin A, Ming L, Robson T, McKeown SR, Worthington J. Butterworth KT, et al. Among authors: worthington j. Int J Cancer. 2008 Aug 15;123(4):760-8. doi: 10.1002/ijc.23418. Int J Cancer. 2008. PMID: 18512241

7

The unidirectional hypoxia-activated prodrug OCT1002 inhibits growth and vascular development in castrate-resistant prostate tumors.

Nesbitt H, Worthington J, Errington RJ, Patterson LH, Smith PJ, McKeown SR, McKenna DJ. Nesbitt H, et al. Among authors: worthington j. Prostate. 2017 Nov;77(15):1539-1547. doi: 10.1002/pros.23434. Epub 2017 Sep 24. Prostate. 2017. PMID: 28944496 Free article.

8

Evaluation of the antiangiogenic potential of AQ4N.

O'Rourke M, Ward C, Worthington J, McKenna J, Valentine A, Robson T, Hirst DG, McKeown SR. O'Rourke M, et al. Among authors: worthington j. Clin Cancer Res. 2008 Mar 1;14(5):1502-9. doi: 10.1158/1078-0432.CCR-07-1262. Clin Cancer Res. 2008. PMID: 18316575 Free article.

9

p21((WAF1))-mediated transcriptional targeting of inducible nitric oxide synthase gene therapy sensitizes tumours to fractionated radiotherapy.

McCarthy HO, Worthington J, Barrett E, Cosimo E, Boyd M, Mairs RJ, Ward C, McKeown SR, Hirst DG, Robson T. McCarthy HO, et al. Among authors: worthington j. Gene Ther. 2007 Feb;14(3):246-55. doi: 10.1038/sj.gt.3302871. Epub 2006 Sep 28. Gene Ther. 2007. PMID: 17006546

10

A study of anti-cancer effects of Funalia trogii in vitro and in vivo.

Rashid S, Unyayar A, Mazmanci MA, McKeown SR, Banat IM, Worthington J. Rashid S, et al. Among authors: worthington j. Food Chem Toxicol. 2011 Jul;49(7):1477-83. doi: 10.1016/j.fct.2011.02.008. Epub 2011 Feb 17. Food Chem Toxicol. 2011. PMID: 21333711

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