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Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.
Perin PM, Haid S, Brown RJ, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FW, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T. Perin PM, et al. Among authors: meuleman p. Hepatology. 2016 Jan;63(1):49-62. doi: 10.1002/hep.28111. Epub 2015 Oct 9. Hepatology. 2016. PMID: 26248546 Free PMC article.
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.
Lindenbach BD, Meuleman P, Ploss A, Vanwolleghem T, Syder AJ, McKeating JA, Lanford RE, Feinstone SM, Major ME, Leroux-Roels G, Rice CM. Lindenbach BD, et al. Among authors: meuleman p. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3805-9. doi: 10.1073/pnas.0511218103. Epub 2006 Feb 16. Proc Natl Acad Sci U S A. 2006. PMID: 16484368 Free PMC article.
Griffithsin has antiviral activity against hepatitis C virus.
Meuleman P, Albecka A, Belouzard S, Vercauteren K, Verhoye L, Wychowski C, Leroux-Roels G, Palmer KE, Dubuisson J. Meuleman P, et al. Antimicrob Agents Chemother. 2011 Nov;55(11):5159-67. doi: 10.1128/AAC.00633-11. Epub 2011 Sep 6. Antimicrob Agents Chemother. 2011. PMID: 21896910 Free PMC article.
130 results