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Benzo[a]pyrene affects Jurkat T cells in the activated state via the antioxidant response element dependent Nrf2 pathway leading to decreased IL-2 secretion and redirecting glutamine metabolism.
Murugaiyan J, Rockstroh M, Wagner J, Baumann S, Schorsch K, Trump S, Lehmann I, Bergen Mv, Tomm JM. Murugaiyan J, et al. Among authors: tomm jm. Toxicol Appl Pharmacol. 2013 Jun 15;269(3):307-16. doi: 10.1016/j.taap.2013.03.032. Epub 2013 Apr 10. Toxicol Appl Pharmacol. 2013. PMID: 23583300
Combined proteomic and metabolomic profiling of serum reveals association of the complement system with obesity and identifies novel markers of body fat mass changes.
Oberbach A, Blüher M, Wirth H, Till H, Kovacs P, Kullnick Y, Schlichting N, Tomm JM, Rolle-Kampczyk U, Murugaiyan J, Binder H, Dietrich A, von Bergen M. Oberbach A, et al. Among authors: tomm jm. J Proteome Res. 2011 Oct 7;10(10):4769-88. doi: 10.1021/pr2005555. Epub 2011 Aug 29. J Proteome Res. 2011. PMID: 21823675
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