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The Fanconi anemia core complex promotes CtIP-dependent end-resection to drive homologous recombination at DNA double-strand breaks.
van de Kooij B, van der Wal FJ, Rother MB, Creixell P, Stout M, Wiegant W, Joughin BA, Vornberger J, van Vugt MATM, Altmeyer M, Yaffe MB, van Attikum H. van de Kooij B, et al. Among authors: van attikum h. bioRxiv [Preprint]. 2023 Sep 6:2023.09.05.556391. doi: 10.1101/2023.09.05.556391. bioRxiv. 2023. Update in: Nat Commun. 2024 Aug 16;15(1):7076. doi: 10.1038/s41467-024-51090-6. PMID: 37732274 Free PMC article. Updated. Preprint.
EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells.
van de Kooij B, Schreuder A, Pavani RS, Garzero V, Van Hoeck A, San Martin Alonso M, Koerse D, Wendel TJ, Callen E, Boom J, Mei H, Cuppen E, Nussenzweig A, van Attikum H, Noordermeer SM. van de Kooij B, et al. Among authors: van attikum h. bioRxiv [Preprint]. 2023 Feb 24:2023.02.24.529205. doi: 10.1101/2023.02.24.529205. bioRxiv. 2023. PMID: 37720033 Free PMC article. Preprint.
Rewiring of genetic networks in response to DNA damage.
Bandyopadhyay S, Mehta M, Kuo D, Sung MK, Chuang R, Jaehnig EJ, Bodenmiller B, Licon K, Copeland W, Shales M, Fiedler D, Dutkowski J, Guénolé A, van Attikum H, Shokat KM, Kolodner RD, Huh WK, Aebersold R, Keogh MC, Krogan NJ, Ideker T. Bandyopadhyay S, et al. Among authors: van attikum h. Science. 2010 Dec 3;330(6009):1385-9. doi: 10.1126/science.1195618. Science. 2010. PMID: 21127252 Free PMC article.
A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.
Srivas R, Costelloe T, Carvunis AR, Sarkar S, Malta E, Sun SM, Pool M, Licon K, van Welsem T, van Leeuwen F, McHugh PJ, van Attikum H, Ideker T. Srivas R, et al. Among authors: van leeuwen f, van welsem t, van attikum h. Cell Rep. 2013 Dec 26;5(6):1714-24. doi: 10.1016/j.celrep.2013.11.035. Epub 2013 Dec 19. Cell Rep. 2013. PMID: 24360959 Free PMC article.
Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.
Hustedt N, Seeber A, Sack R, Tsai-Pflugfelder M, Bhullar B, Vlaming H, van Leeuwen F, Guénolé A, van Attikum H, Srivas R, Ideker T, Shimada K, Gasser SM. Hustedt N, et al. Among authors: van leeuwen f, van attikum h. Mol Cell. 2015 Jan 22;57(2):273-89. doi: 10.1016/j.molcel.2014.11.016. Epub 2014 Dec 18. Mol Cell. 2015. PMID: 25533186 Free PMC article.
A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.
Srivas R, Shen JP, Yang CC, Sun SM, Li J, Gross AM, Jensen J, Licon K, Bojorquez-Gomez A, Klepper K, Huang J, Pekin D, Xu JL, Yeerna H, Sivaganesh V, Kollenstart L, van Attikum H, Aza-Blanc P, Sobol RW, Ideker T. Srivas R, et al. Among authors: van attikum h. Mol Cell. 2016 Aug 4;63(3):514-25. doi: 10.1016/j.molcel.2016.06.022. Epub 2016 Jul 21. Mol Cell. 2016. PMID: 27453043 Free PMC article.
97 results