Wootten D - Search Results

1

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.

Wootten D, Reynolds CA, Koole C, Smith KJ, Mobarec JC, Simms J, Quon T, Coudrat T, Furness SG, Miller LJ, Christopoulos A, Sexton PM. Wootten D, et al. Mol Pharmacol. 2016 Mar;89(3):335-47. doi: 10.1124/mol.115.101246. Epub 2015 Dec 23. Mol Pharmacol. 2016. PMID: 26700562 Free PMC article.

2

Diverse functional motifs within the three intracellular loops of the CGRP1 receptor.

Conner AC, Simms J, Conner MT, Wootten DL, Wheatley M, Poyner DR. Conner AC, et al. Biochemistry. 2006 Oct 31;45(43):12976-85. doi: 10.1021/bi0615801. Biochemistry. 2006. PMID: 17059214

3

Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.

Conner M, Hawtin SR, Simms J, Wootten D, Lawson Z, Conner AC, Parslow RA, Wheatley M. Conner M, et al. Among authors: wootten d. J Biol Chem. 2007 Jun 15;282(24):17405-12. doi: 10.1074/jbc.M702151200. Epub 2007 Apr 2. J Biol Chem. 2007. PMID: 17403667 Free article.

4

Extracellular loops and ligand binding to a subfamily of Family A G-protein-coupled receptors.

Wheatley M, Simms J, Hawtin SR, Wesley VJ, Wootten D, Conner M, Lawson Z, Conner AC, Baker A, Cashmore Y, Kendrick R, Parslow RA. Wheatley M, et al. Among authors: wootten d. Biochem Soc Trans. 2007 Aug;35(Pt 4):717-20. doi: 10.1042/BST0350717. Biochem Soc Trans. 2007. PMID: 17635132 Review.

5

Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

Koole C, Wootten D, Simms J, Valant C, Sridhar R, Woodman OL, Miller LJ, Summers RJ, Christopoulos A, Sexton PM. Koole C, et al. Among authors: wootten d. Mol Pharmacol. 2010 Sep;78(3):456-65. doi: 10.1124/mol.110.065664. Epub 2010 Jun 14. Mol Pharmacol. 2010. PMID: 20547734 Free PMC article.

6

Receptor activity modifying proteins and their potential as drug targets.

Wootten DL, Simms J, Hay DL, Christopoulos A, Sexton PM. Wootten DL, et al. Prog Mol Biol Transl Sci. 2010;91:53-79. doi: 10.1016/S1877-1173(10)91003-X. Prog Mol Biol Transl Sci. 2010. PMID: 20691959 Review.

7

Modulation of the glucagon-like peptide-1 receptor signaling by naturally occurring and synthetic flavonoids.

Wootten D, Simms J, Koole C, Woodman OL, Summers RJ, Christopoulos A, Sexton PM. Wootten D, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):540-50. doi: 10.1124/jpet.110.176362. Epub 2010 Nov 12. J Pharmacol Exp Ther. 2011. PMID: 21075839

8

Agonist-specific requirement for a glutamate in transmembrane helix 1 of the oxytocin receptor.

Wootten DL, Simms J, Massoura AJ, Trim JE, Wheatley M. Wootten DL, et al. Mol Cell Endocrinol. 2011 Feb 10;333(1):20-7. doi: 10.1016/j.mce.2010.11.029. Epub 2010 Dec 3. Mol Cell Endocrinol. 2011. PMID: 21130837

9

Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation.

Koole C, Wootten D, Simms J, Valant C, Miller LJ, Christopoulos A, Sexton PM. Koole C, et al. Among authors: wootten d. Mol Pharmacol. 2011 Sep;80(3):486-97. doi: 10.1124/mol.111.072884. Epub 2011 May 26. Mol Pharmacol. 2011. PMID: 21616920 Free PMC article.

10

Consequences of splice variation on Secretin family G protein-coupled receptor function.

Furness SG, Wootten D, Christopoulos A, Sexton PM. Furness SG, et al. Among authors: wootten d. Br J Pharmacol. 2012 May;166(1):98-109. doi: 10.1111/j.1476-5381.2011.01571.x. Br J Pharmacol. 2012. PMID: 21718310 Free PMC article. Review.

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