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Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.
Green JL, Moon RW, Whalley D, Bowyer PW, Wallace C, Rochani A, Nageshan RK, Howell SA, Grainger M, Jones HM, Ansell KH, Chapman TM, Taylor DL, Osborne SA, Baker DA, Tatu U, Holder AA. Green JL, et al. Among authors: jones hm. Antimicrob Agents Chemother. 2015 Dec 28;60(3):1464-75. doi: 10.1128/AAC.01748-15. Antimicrob Agents Chemother. 2015. PMID: 26711771 Free PMC article.
Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
Chapman TM, Osborne SA, Bouloc N, Large JM, Wallace C, Birchall K, Ansell KH, Jones HM, Taylor D, Clough B, Green JL, Holder AA. Chapman TM, et al. Among authors: jones hm. Bioorg Med Chem Lett. 2013 May 15;23(10):3064-9. doi: 10.1016/j.bmcl.2013.03.017. Epub 2013 Mar 21. Bioorg Med Chem Lett. 2013. PMID: 23570789 Free PMC article.
Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues.
Large JM, Osborne SA, Smiljanic-Hurley E, Ansell KH, Jones HM, Taylor DL, Clough B, Green JL, Holder AA. Large JM, et al. Among authors: jones hm. Bioorg Med Chem Lett. 2013 Nov 1;23(21):6019-24. doi: 10.1016/j.bmcl.2013.08.010. Epub 2013 Aug 11. Bioorg Med Chem Lett. 2013. PMID: 24035097 Free PMC article.
Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1.
Ansell KH, Jones HM, Whalley D, Hearn A, Taylor DL, Patin EC, Chapman TM, Osborne SA, Wallace C, Birchall K, Large J, Bouloc N, Smiljanic-Hurley E, Clough B, Moon RW, Green JL, Holder AA. Ansell KH, et al. Among authors: jones hm. Antimicrob Agents Chemother. 2014 Oct;58(10):6032-43. doi: 10.1128/AAC.02959-14. Epub 2014 Jul 28. Antimicrob Agents Chemother. 2014. PMID: 25070106 Free PMC article.
Discovery of electrophilic degraders that exploit SNAr chemistry.
Zhuang Z, Byun WS, Kozicka Z, Dwyer BG, Donovan KA, Jiang Z, Jones HM, Abeja DM, Nix MN, Zhong J, Słabicki M, Fischer ES, Ebert BL, Gray NS. Zhuang Z, et al. Among authors: jones hm. bioRxiv [Preprint]. 2024 Sep 27:2024.09.25.615094. doi: 10.1101/2024.09.25.615094. bioRxiv. 2024. PMID: 39386645 Free PMC article. Preprint.
Major Publications in the Critical Care Pharmacotherapy Literature: 2023.
Murray B, Athale J, Balk RA, Behal ML, Brown JE, Chanas T, Dumitru R, Gifford DC, Hohlfelder B, Jones HM, Makic MBF, Rausen MS, Sacco AJ, Sines BJ, Gurnani PK. Murray B, et al. Among authors: jones hm. Crit Care Explor. 2024 Oct 3;6(10):e1162. doi: 10.1097/CCE.0000000000001162. eCollection 2024 Oct 1. Crit Care Explor. 2024. PMID: 39360775 Free PMC article. Review.
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