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New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.
Huynh TH, Erichsen MN, Tora AS, Goudet C, Sagot E, Assaf Z, Thomsen C, Brodbeck R, Stensbøl TB, Bjørn-Yoshimoto WE, Nielsen B, Pin JP, Gefflaut T, Bunch L. Huynh TH, et al. Among authors: thomsen c. J Med Chem. 2016 Feb 11;59(3):914-24. doi: 10.1021/acs.jmedchem.5b01333. Epub 2016 Jan 27. J Med Chem. 2016. PMID: 26814576
Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.
Hopper AT, Juhl M, Hornberg J, Badolo L, Kilburn JP, Thougaard A, Smagin G, Song D, Calice L, Menon V, Dale E, Zhang H, Cajina M, Nattini ME, Gandhi A, Grenon M, Jones K, Khayrullina T, Chandrasena G, Thomsen C, Zorn SH, Brodbeck R, Poda SB, Staal R, Möller T. Hopper AT, et al. Among authors: thomsen c. J Med Chem. 2021 Apr 22;64(8):4891-4902. doi: 10.1021/acs.jmedchem.0c02249. Epub 2021 Apr 6. J Med Chem. 2021. PMID: 33822617
Synthesis and preliminary biological evaluation of 2'-substituted 2-(3'-carboxybicyclo[1.1.1]pentyl)glycine derivatives as group I selective metabotropic glutamate receptor ligands.
Pellicciari R, Filosa R, Fulco MC, Marinozzi M, Macchiarulo A, Novak C, Natalini B, Hermit MB, Nielsen S, Sager TN, Stensbøl TB, Thomsen C. Pellicciari R, et al. Among authors: thomsen c. ChemMedChem. 2006 Mar;1(3):358-65. doi: 10.1002/cmdc.200500071. ChemMedChem. 2006. PMID: 16892370
Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2'-carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a novel and selective group II metabotropic glutamate receptors antagonist.
Pellicciari R, Marinozzi M, Natalini B, Costantino G, Luneia R, Giorgi G, Moroni F, Thomsen C. Pellicciari R, et al. Among authors: thomsen c. J Med Chem. 1996 May 24;39(11):2259-69. doi: 10.1021/jm960059+. J Med Chem. 1996. PMID: 8667369
Synthesis, molecular modeling studies, and preliminary pharmacological characterization of all possible 2-(2'-sulfonocyclopropyl)glycine stereoisomers as conformationally constrained L-homocysteic acid analogs.
Pellicciari R, Marinozzi M, Macchiarulo A, Fulco MC, Gafarova J, Serpi M, Giorgi G, Nielsen S, Thomsen C. Pellicciari R, et al. Among authors: thomsen c. J Med Chem. 2007 Sep 20;50(19):4630-41. doi: 10.1021/jm070322e. Epub 2007 Aug 29. J Med Chem. 2007. PMID: 17725337
861 results