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Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.
Cheng X, Kim JY, Ghafoory S, Duvaci T, Rafiee R, Theobald J, Alborzinia H, Holenya P, Fredebohm J, Merz KH, Mehrabi A, Hafezi M, Saffari A, Eisenbrand G, Hoheisel JD, Wölfl S. Cheng X, et al. Among authors: hoheisel jd. Mol Oncol. 2016 Jun;10(6):806-24. doi: 10.1016/j.molonc.2016.01.008. Epub 2016 Feb 4. Mol Oncol. 2016. PMID: 26887594 Free PMC article.
Decoding pooled RNAi screens by means of barcode tiling arrays.
Boettcher M, Fredebohm J, Gholami AM, Hachmo Y, Dotan I, Canaani D, Hoheisel JD. Boettcher M, et al. Among authors: hoheisel jd. BMC Genomics. 2010 Jan 5;11:7. doi: 10.1186/1471-2164-11-7. BMC Genomics. 2010. PMID: 20051122 Free PMC article.
Establishment and characterization of a highly tumourigenic and cancer stem cell enriched pancreatic cancer cell line as a well defined model system.
Fredebohm J, Boettcher M, Eisen C, Gaida MM, Heller A, Keleg S, Tost J, Greulich-Bode KM, Hotz-Wagenblatt A, Lathrop M, Giese NA, Hoheisel JD. Fredebohm J, et al. Among authors: hoheisel jd. PLoS One. 2012;7(11):e48503. doi: 10.1371/journal.pone.0048503. Epub 2012 Nov 12. PLoS One. 2012. PMID: 23152778 Free PMC article.
Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.
Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, Wendler S, Männle D, Hinz U, Sticht C, Muciek M, Gretz N, Rose AJ, Greiner V, Hofmann TG, Bauer A, Hoheisel J, Berriel Diaz M, Gaida MM, Werner J, Schafmeier T, Strobel O, Herzig S. Stoy C, et al. EMBO Mol Med. 2015 Aug;7(8):1048-62. doi: 10.15252/emmm.201404837. EMBO Mol Med. 2015. PMID: 26070712 Free PMC article.
NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice.
Cheng X, Haeberle S, Shytaj IL, Gama-Brambila RA, Theobald J, Ghafoory S, Wölker J, Basu U, Schmidt C, Timm A, Taškova K, Bauer AS, Hoheisel J, Tsopoulidis N, Fackler OT, Savarino A, Andrade-Navarro MA, Ott I, Lusic M, Hadaschik EN, Wölfl S. Cheng X, et al. Commun Biol. 2020 Jan 3;3:10. doi: 10.1038/s42003-019-0716-8. eCollection 2020. Commun Biol. 2020. PMID: 31909202 Free PMC article.
SST gene hypermethylation acts as a pan-cancer marker for pancreatic ductal adenocarcinoma and multiple other tumors: toward its use for blood-based diagnosis.
Manoochehri M, Wu Y, Giese NA, Strobel O, Kutschmann S, Haller F, Hoheisel JD, Moskalev EA, Hackert T, Bauer AS. Manoochehri M, et al. Among authors: hoheisel jd. Mol Oncol. 2020 Jun;14(6):1252-1267. doi: 10.1002/1878-0261.12684. Epub 2020 Apr 14. Mol Oncol. 2020. PMID: 32243066 Free PMC article.
280 results