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Page 1
Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.
Sawyer TK, Partridge AW, Kaan HYK, Juang YC, Lim S, Johannes C, Yuen TY, Verma C, Kannan S, Aronica P, Tan YS, Sherborne B, Ha S, Hochman J, Chen S, Surdi L, Peier A, Sauvagnat B, Dandliker PJ, Brown CJ, Ng S, Ferrer F, Lane DP. Sawyer TK, et al. Among authors: tan ys. Bioorg Med Chem. 2018 Jun 1;26(10):2807-2815. doi: 10.1016/j.bmc.2018.03.008. Epub 2018 Mar 16. Bioorg Med Chem. 2018. PMID: 29598901
Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties.
Partridge AW, Kaan HYK, Juang YC, Sadruddin A, Lim S, Brown CJ, Ng S, Thean D, Ferrer F, Johannes C, Yuen TY, Kannan S, Aronica P, Tan YS, Pradhan MR, Verma CS, Hochman J, Chen S, Wan H, Ha S, Sherborne B, Lane DP, Sawyer TK. Partridge AW, et al. Among authors: tan ys. Molecules. 2019 Jun 20;24(12):2292. doi: 10.3390/molecules24122292. Molecules. 2019. PMID: 31226791 Free PMC article.
Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability.
Kannan S, Aronica PGA, Ng S, Gek Lian DT, Frosi Y, Chee S, Shimin J, Yuen TY, Sadruddin A, Kaan HYK, Chandramohan A, Wong JH, Tan YS, Chang ZW, Ferrer-Gago FJ, Arumugam P, Han Y, Chen S, Rénia L, Brown CJ, Johannes CW, Henry B, Lane DP, Sawyer TK, Verma CS, Partridge AW. Kannan S, et al. Among authors: tan ys. Chem Sci. 2020 May 11;11(21):5577-5591. doi: 10.1039/c9sc06383h. eCollection 2020 Jun 7. Chem Sci. 2020. PMID: 32874502 Free PMC article.
338 results