Reilly J - Search Results

1

Uncoupling the Structure-Activity Relationships of β2 Adrenergic Receptor Ligands from Membrane Binding.

Dickson CJ, Hornak V, Velez-Vega C, McKay DJ, Reilly J, Sandham DA, Shaw D, Fairhurst RA, Charlton SJ, Sykes DA, Pearlstein RA, Duca JS. Dickson CJ, et al. Among authors: reilly j. J Med Chem. 2016 Jun 23;59(12):5780-9. doi: 10.1021/acs.jmedchem.6b00358. Epub 2016 Jun 7. J Med Chem. 2016. PMID: 27239696

2

7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.

Sandham DA, Adcock C, Bala K, Barker L, Brown Z, Dubois G, Budd D, Cox B, Fairhurst RA, Furegati M, Leblanc C, Manini J, Profit R, Reilly J, Stringer R, Schmidt A, Turner KL, Watson SJ, Willis J, Williams G, Wilson C. Sandham DA, et al. Among authors: reilly j. Bioorg Med Chem Lett. 2009 Aug 15;19(16):4794-8. doi: 10.1016/j.bmcl.2009.06.042. Epub 2009 Jun 14. Bioorg Med Chem Lett. 2009. PMID: 19592244

3

The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.

Baur F, Beattie D, Beer D, Bentley D, Bradley M, Bruce I, Charlton SJ, Cuenoud B, Ernst R, Fairhurst RA, Faller B, Farr D, Keller T, Fozard JR, Fullerton J, Garman S, Hatto J, Hayden C, He H, Howes C, Janus D, Jiang Z, Lewis C, Loeuillet-Ritzler F, Moser H, Reilly J, Steward A, Sykes D, Tedaldi L, Trifilieff A, Tweed M, Watson S, Wissler E, Wyss D. Baur F, et al. Among authors: reilly j. J Med Chem. 2010 May 13;53(9):3675-84. doi: 10.1021/jm100068m. J Med Chem. 2010. PMID: 20402514

4

Synthesis of useful fragments in drug discovery: 2-Amino-5-tert-butylpyridine and its oxidised analogues.

Thomson CG, Reilly J, Sandham DA. Thomson CG, et al. Among authors: reilly j. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4281-3. doi: 10.1016/j.bmcl.2011.05.066. Epub 2011 May 25. Bioorg Med Chem Lett. 2011. PMID: 21669523

5

The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists.

Porter DW, Bradley M, Brown Z, Canova R, Charlton S, Cox B, Hunt P, Kolarik D, Lewis S, O'Connor D, Reilly J, Spanka C, Tedaldi L, Watson SJ, Wermuth R, Press NJ. Porter DW, et al. Among authors: reilly j. Bioorg Med Chem Lett. 2014 Jan 1;24(1):72-6. doi: 10.1016/j.bmcl.2013.11.074. Epub 2013 Dec 4. Bioorg Med Chem Lett. 2014. PMID: 24332493

6

Observed drug-receptor association rates are governed by membrane affinity: the importance of establishing "micro-pharmacokinetic/pharmacodynamic relationships" at the β2-adrenoceptor.

Sykes DA, Parry C, Reilly J, Wright P, Fairhurst RA, Charlton SJ. Sykes DA, et al. Among authors: reilly j. Mol Pharmacol. 2014 Apr;85(4):608-17. doi: 10.1124/mol.113.090209. Epub 2014 Jan 29. Mol Pharmacol. 2014. PMID: 24476583

7

The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists.

Porter DW, Bradley M, Brown Z, Charlton SJ, Cox B, Hunt P, Janus D, Lewis S, Oakley P, O'Connor D, Reilly J, Smith N, Press NJ. Porter DW, et al. Among authors: reilly j. Bioorg Med Chem Lett. 2014 Aug 1;24(15):3285-90. doi: 10.1016/j.bmcl.2014.06.011. Epub 2014 Jun 14. Bioorg Med Chem Lett. 2014. PMID: 24974342

8

Structure-kinetic relationship of carbapenem antibacterials permeating through E. coli OmpC porin.

Tran QT, Pearlstein RA, Williams S, Reilly J, Krucker T, Erdemli G. Tran QT, et al. Among authors: reilly j. Proteins. 2014 Nov;82(11):2998-3012. doi: 10.1002/prot.24659. Epub 2014 Aug 21. Proteins. 2014. PMID: 25082756

9

Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for Improved Clinical Efficacy.

Sykes DA, Bradley ME, Riddy DM, Willard E, Reilly J, Miah A, Bauer C, Watson SJ, Sandham DA, Dubois G, Charlton SJ. Sykes DA, et al. Among authors: reilly j. Mol Pharmacol. 2016 May;89(5):593-605. doi: 10.1124/mol.115.101832. Epub 2016 Feb 25. Mol Pharmacol. 2016. PMID: 26916831

10

Ligand Specific Efficiency (LSE) Index for PET Tracer Optimization.

Auberson YP, Briard E, Sykes D, Reilly J, Healy M. Auberson YP, et al. Among authors: reilly j. ChemMedChem. 2016 Jul 5;11(13):1415-27. doi: 10.1002/cmdc.201600112. Epub 2016 May 19. ChemMedChem. 2016. PMID: 27193393

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