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Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.
Girard R, Zeineddine HA, Orsbon C, Tan H, Moore T, Hobson N, Shenkar R, Lightle R, Shi C, Fam MD, Cao Y, Shen L, Neander AI, Rorrer A, Gallione C, Tang AT, Kahn ML, Marchuk DA, Luo ZX, Awad IA. Girard R, et al. Among authors: hobson n. J Neurosci Methods. 2016 Sep 15;271:14-24. doi: 10.1016/j.jneumeth.2016.06.021. Epub 2016 Jun 23. J Neurosci Methods. 2016. PMID: 27345427 Free PMC article.
Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.
Tang AT, Choi JP, Kotzin JJ, Yang Y, Hong CC, Hobson N, Girard R, Zeineddine HA, Lightle R, Moore T, Cao Y, Shenkar R, Chen M, Mericko P, Yang J, Li L, Tanes C, Kobuley D, Võsa U, Whitehead KJ, Li DY, Franke L, Hart B, Schwaninger M, Henao-Mejia J, Morrison L, Kim H, Awad IA, Zheng X, Kahn ML. Tang AT, et al. Among authors: hobson n. Nature. 2017 May 18;545(7654):305-310. doi: 10.1038/nature22075. Epub 2017 May 10. Nature. 2017. PMID: 28489816 Free PMC article.
Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage.
Zeineddine HA, Girard R, Cao Y, Hobson N, Fam MD, Stadnik A, Tan H, Shen J, Chaudagar K, Shenkar R, Thompson RE, McBee N, Hanley D, Carroll T, Christoforidis GA, Awad IA. Zeineddine HA, et al. Among authors: hobson n. J Magn Reson Imaging. 2018 Apr;47(4):1133-1138. doi: 10.1002/jmri.25831. Epub 2017 Aug 9. J Magn Reson Imaging. 2018. PMID: 28791783 Free PMC article.
Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
Shenkar R, Peiper A, Pardo H, Moore T, Lightle R, Girard R, Hobson N, Polster SP, Koskimäki J, Zhang D, Lyne SB, Cao Y, Chaudagar K, Saadat L, Gallione C, Pytel P, Liao JK, Marchuk D, Awad IA. Shenkar R, et al. Among authors: hobson n. Stroke. 2019 Mar;50(3):738-744. doi: 10.1161/STROKEAHA.118.024058. Stroke. 2019. PMID: 30744543 Free PMC article.
A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
McKerracher L, Shenkar R, Abbinanti M, Cao Y, Peiper A, Liao JK, Lightle R, Moore T, Hobson N, Gallione C, Ruschel J, Koskimäki J, Girard R, Rosen K, Marchuk DA, Awad IA. McKerracher L, et al. Among authors: hobson n. Transl Stroke Res. 2020 Jun;11(3):365-376. doi: 10.1007/s12975-019-00725-8. Epub 2019 Aug 24. Transl Stroke Res. 2020. PMID: 31446620 Free PMC article.
Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican.
Hong CC, Tang AT, Detter MR, Choi JP, Wang R, Yang X, Guerrero AA, Wittig CF, Hobson N, Girard R, Lightle R, Moore T, Shenkar R, Polster SP, Goddard LM, Ren AA, Leu NA, Sterling S, Yang J, Li L, Chen M, Mericko-Ishizuka P, Dow LE, Watanabe H, Schwaninger M, Min W, Marchuk DA, Zheng X, Awad IA, Kahn ML. Hong CC, et al. Among authors: hobson n. J Exp Med. 2020 Oct 5;217(10):e20200140. doi: 10.1084/jem.20200140. J Exp Med. 2020. PMID: 32648916 Free PMC article.
Novel Murine Models of Cerebral Cavernous Malformations.
Detter MR, Shenkar R, Benavides CR, Neilson CA, Moore T, Lightle R, Hobson N, Shen L, Cao Y, Girard R, Zhang D, Griffin E, Gallione CJ, Awad IA, Marchuk DA. Detter MR, et al. Among authors: hobson n. Angiogenesis. 2020 Nov;23(4):651-666. doi: 10.1007/s10456-020-09736-8. Epub 2020 Jul 24. Angiogenesis. 2020. PMID: 32710309 Free PMC article.
Propranolol as therapy for cerebral cavernous malformations: a cautionary note.
Shenkar R, Moore T, Benavides C, Lightle R, Detter MR, Hobson N, Girard R, DeBiasse D, Patrucco M, Gallione C, Zabramski JM, Marchuk DA, Awad IA. Shenkar R, et al. Among authors: hobson n. J Transl Med. 2022 Apr 5;20(1):160. doi: 10.1186/s12967-022-03360-4. J Transl Med. 2022. PMID: 35382850 Free PMC article. No abstract available.
84 results