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Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.
Allen JG, Mujacic M, Frohn MJ, Pickrell AJ, Kodama P, Bagal D, San Miguel T, Sickmier EA, Osgood S, Swietlow A, Li V, Jordan JB, Kim KW, Rousseau AC, Kim YJ, Caille S, Achmatowicz M, Thiel O, Fotsch CH, Reddy P, McCarter JD. Allen JG, et al. Among authors: swietlow a. ACS Chem Biol. 2016 Oct 21;11(10):2734-2743. doi: 10.1021/acschembio.6b00460. Epub 2016 Aug 11. ACS Chem Biol. 2016. PMID: 27434622
Telescoped Process to Manufacture 6,6,6-Trifluorofucose via Diastereoselective Transfer Hydrogenation: Scalable Access to an Inhibitor of Fucosylation Utilized in Monoclonal Antibody Production.
Achmatowicz MM, Allen JG, Bio MM, Bartberger MD, Borths CJ, Colyer JT, Crockett RD, Hwang TL, Koek JN, Osgood SA, Roberts SW, Swietlow A, Thiel OR, Caille S. Achmatowicz MM, et al. Among authors: swietlow a. J Org Chem. 2016 Jun 3;81(11):4736-43. doi: 10.1021/acs.joc.6b00646. Epub 2016 May 20. J Org Chem. 2016. PMID: 27152753