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Role of hepatic blood flow and metabolism in the pharmacokinetics of ten drugs in lean, aged and obese rats.
Subramanian M, Kurawattimath V, Pocha K, Freeden C, Rao I, Mariappan TT, Marathe PH, Vikramadithyan RK, Abraham P, Kulkarni CP, Katnapally P, Nutakki R, Paruchury S, Bhutani P, Mandlekar S. Subramanian M, et al. Among authors: bhutani p. Xenobiotica. 2014 Dec;44(12):1108-16. doi: 10.3109/00498254.2014.932470. Epub 2014 Jun 20. Xenobiotica. 2014. PMID: 24947446
Absorption and cleavage of enalapril, a carboxyl ester prodrug, in the rat intestine: in vitro, in situ intestinal perfusion and portal vein cannulation models.
Holenarsipur VK, Gaud N, Sinha J, Sivaprasad S, Bhutani P, Subramanian M, Singh SP, Arla R, Paruchury S, Sharma T, Marathe P, Mandlekar S. Holenarsipur VK, et al. Among authors: bhutani p. Biopharm Drug Dispos. 2015 Sep;36(6):385-397. doi: 10.1002/bdd.1950. Epub 2015 May 4. Biopharm Drug Dispos. 2015. PMID: 25832562
(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.
Subbaiah MAM, Ramar T, Subramani L, Desai SD, Sinha S, Mandlekar S, Jenkins SM, Krystal MR, Subramanian M, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Kadow JF, Meanwell NA. Subbaiah MAM, et al. Among authors: bhutani p. Eur J Med Chem. 2020 Dec 1;207:112749. doi: 10.1016/j.ejmech.2020.112749. Epub 2020 Aug 21. Eur J Med Chem. 2020. PMID: 33065417
Improving Drug Delivery While Tailoring Prodrug Activation to Modulate Cmax and Cmin by Optimization of (Carbonyl)oxyalkyl Linker-Based Prodrugs of Atazanavir.
A M Subbaiah M, Subramani L, Ramar T, Desai S, Sinha S, Mandlekar S, Kadow JF, Jenkins S, Krystal M, Subramanian M, Sridhar S, Padmanabhan S, Bhutani P, Arla R, Meanwell NA. A M Subbaiah M, et al. Among authors: bhutani p. J Med Chem. 2022 Aug 25;65(16):11150-11176. doi: 10.1021/acs.jmedchem.2c00632. Epub 2022 Aug 11. J Med Chem. 2022. PMID: 35952307
27 results