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Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.
Al-Hashimi AA, Lebeau P, Majeed F, Polena E, Lhotak Š, Collins CAF, Pinthus JH, Gonzalez-Gronow M, Hoogenes J, Pizzo SV, Crowther M, Kapoor A, Rak J, Gyulay G, D'Angelo S, Marchiò S, Pasqualini R, Arap W, Shayegan B, Austin RC. Al-Hashimi AA, et al. Among authors: gyulay g. J Biol Chem. 2017 Dec 22;292(51):21180-21192. doi: 10.1074/jbc.M117.799908. Epub 2017 Oct 24. J Biol Chem. 2017. PMID: 29066620 Free PMC article.
Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.
Lebeau P, Platko K, Al-Hashimi AA, Byun JH, Lhoták Š, Holzapfel N, Gyulay G, Igdoura SA, Cool DR, Trigatti B, Seidah NG, Austin RC. Lebeau P, et al. Among authors: gyulay g. J Biol Chem. 2018 May 11;293(19):7329-7343. doi: 10.1074/jbc.RA117.001049. Epub 2018 Mar 28. J Biol Chem. 2018. PMID: 29593095 Free PMC article.
Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice.
White EJ, Gyulay G, Lhoták Š, Szewczyk MM, Chong T, Fuller MT, Dadoo O, Fox-Robichaud AE, Austin RC, Trigatti BL, Igdoura SA. White EJ, et al. Among authors: gyulay g. J Biol Chem. 2018 Sep 21;293(38):14689-14706. doi: 10.1074/jbc.RA118.004589. Epub 2018 Aug 10. J Biol Chem. 2018. PMID: 30097518 Free PMC article.
TDAG51 (T-Cell Death-Associated Gene 51) Is a Key Modulator of Vascular Calcification and Osteogenic Transdifferentiation of Arterial Smooth Muscle Cells.
Platko K, Lebeau PF, Gyulay G, Lhoták Š, MacDonald ME, Pacher G, Hyun Byun J, Boivin FJ, Igdoura SA, Cutz JC, Bridgewater D, Ingram AJ, Krepinsky JC, Austin RC. Platko K, et al. Among authors: gyulay g. Arterioscler Thromb Vasc Biol. 2020 Jul;40(7):1664-1679. doi: 10.1161/ATVBAHA.119.313779. Epub 2020 May 21. Arterioscler Thromb Vasc Biol. 2020. PMID: 32434409 Free article.
GDF10 is a negative regulator of vascular calcification.
Platko K, Gyulay G, Lebeau PF, MacDonald ME, Lynn EG, Byun JH, Igdoura SA, Holden RM, Roubtsova A, Seidah NG, Krepinsky JC, Austin RC. Platko K, et al. Among authors: gyulay g. J Biol Chem. 2024 Sep 21;300(11):107805. doi: 10.1016/j.jbc.2024.107805. Online ahead of print. J Biol Chem. 2024. PMID: 39307303 Free article.
11 results