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Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor.
Wootten D, Reynolds CA, Smith KJ, Mobarec JC, Furness SG, Miller LJ, Christopoulos A, Sexton PM. Wootten D, et al. Among authors: christopoulos a. Biochem Pharmacol. 2016 Oct 15;118:68-87. doi: 10.1016/j.bcp.2016.08.015. Epub 2016 Aug 26. Biochem Pharmacol. 2016. PMID: 27569426 Free PMC article.
Novel receptor partners and function of receptor activity-modifying proteins.
Christopoulos A, Christopoulos G, Morfis M, Udawela M, Laburthe M, Couvineau A, Kuwasako K, Tilakaratne N, Sexton PM. Christopoulos A, et al. Among authors: christopoulos g. J Biol Chem. 2003 Jan 31;278(5):3293-7. doi: 10.1074/jbc.C200629200. Epub 2002 Nov 21. J Biol Chem. 2003. PMID: 12446722 Free article.
RAMPs: 5 years on, where to now?
Morfis M, Christopoulos A, Sexton PM. Morfis M, et al. Among authors: christopoulos a. Trends Pharmacol Sci. 2003 Nov;24(11):596-601. doi: 10.1016/j.tips.2003.09.001. Trends Pharmacol Sci. 2003. PMID: 14607083 Review.
Allosteric modulation of G protein-coupled receptors.
May LT, Avlani VA, Sexton PM, Christopoulos A. May LT, et al. Among authors: christopoulos a. Curr Pharm Des. 2004;10(17):2003-13. doi: 10.2174/1381612043384303. Curr Pharm Des. 2004. PMID: 15279541 Review.
Amylin receptors: molecular composition and pharmacology.
Hay DL, Christopoulos G, Christopoulos A, Sexton PM. Hay DL, et al. Among authors: christopoulos a, christopoulos g. Biochem Soc Trans. 2004 Nov;32(Pt 5):865-7. doi: 10.1042/BST0320865. Biochem Soc Trans. 2004. PMID: 15494035 Review.
445 results