Drinkwater N - Search Results

1

Circumventing the stability-function trade-off in an engineered FN3 domain.

Porebski BT, Conroy PJ, Drinkwater N, Schofield P, Vazquez-Lombardi R, Hunter MR, Hoke DE, Christ D, McGowan S, Buckle AM. Porebski BT, et al. Among authors: drinkwater n. Protein Eng Des Sel. 2016 Nov 1;29(11):541-550. doi: 10.1093/protein/gzw046. Protein Eng Des Sel. 2016. PMID: 27578887 Free PMC article.

2

From crystal to compound: structure-based antimalarial drug discovery.

Drinkwater N, McGowan S. Drinkwater N, et al. Biochem J. 2014 Aug 1;461(3):349-69. doi: 10.1042/BJ20140240. Biochem J. 2014. PMID: 25008945 Review.

3

X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.

Drinkwater N, Bamert RS, Sivaraman KK, Paiardini A, McGowan S. Drinkwater N, et al. Proteins. 2015 Apr;83(4):789-95. doi: 10.1002/prot.24771. Epub 2015 Feb 28. Proteins. 2015. PMID: 25645579

4

Screening the Medicines for Malaria Venture "Malaria Box" against the Plasmodium falciparum aminopeptidases, M1, M17 and M18.

Paiardini A, Bamert RS, Kannan-Sivaraman K, Drinkwater N, Mistry SN, Scammells PJ, McGowan S. Paiardini A, et al. Among authors: drinkwater n. PLoS One. 2015 Feb 20;10(2):e0115859. doi: 10.1371/journal.pone.0115859. eCollection 2015. PLoS One. 2015. PMID: 25700165 Free PMC article.

5

Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate.

Morales RAV, MacRaild CA, Seow J, Krishnarjuna B, Drinkwater N, Rouet R, Anders RF, Christ D, McGowan S, Norton RS. Morales RAV, et al. Among authors: drinkwater n. Sci Rep. 2015 May 12;5:10103. doi: 10.1038/srep10103. Sci Rep. 2015. PMID: 25965408 Free PMC article.

6

Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.

Ruggeri C, Drinkwater N, Sivaraman KK, Bamert RS, McGowan S, Paiardini A. Ruggeri C, et al. Among authors: drinkwater n. PLoS One. 2015 Sep 25;10(9):e0138957. doi: 10.1371/journal.pone.0138957. eCollection 2015. PLoS One. 2015. PMID: 26406322 Free PMC article.

7

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions.

Drinkwater N, Vinh NB, Mistry SN, Bamert RS, Ruggeri C, Holleran JP, Loganathan S, Paiardini A, Charman SA, Powell AK, Avery VM, McGowan S, Scammells PJ. Drinkwater N, et al. Eur J Med Chem. 2016 Mar 3;110:43-64. doi: 10.1016/j.ejmech.2016.01.015. Epub 2016 Jan 13. Eur J Med Chem. 2016. PMID: 26807544

8

Structure-Activity Studies of β-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction.

Wang G, Drinkwater N, Drew DR, MacRaild CA, Chalmers DK, Mohanty B, Lim SS, Anders RF, Beeson JG, Thompson PE, McGowan S, Simpson JS, Norton RS, Scanlon MJ. Wang G, et al. Among authors: drinkwater n. J Mol Biol. 2016 Oct 9;428(20):3986-3998. doi: 10.1016/j.jmb.2016.07.001. Epub 2016 Jul 14. J Mol Biol. 2016. PMID: 27422009

9

Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.

Drinkwater N, Sivaraman KK, Bamert RS, Rut W, Mohamed K, Vinh NB, Scammells PJ, Drag M, McGowan S. Drinkwater N, et al. Biochem J. 2016 Oct 1;473(19):3189-204. doi: 10.1042/BCJ20160550. Epub 2016 Jul 26. Biochem J. 2016. PMID: 27462122

10

X-ray crystal structure of cytochrome P450 monooxygenase CYP101J2 from Sphingobium yanoikuyae strain B2.

Unterweger B, Drinkwater N, Johanesen P, Lyras D, Dumsday GJ, McGowan S. Unterweger B, et al. Among authors: drinkwater n. Proteins. 2017 May;85(5):945-950. doi: 10.1002/prot.25227. Epub 2017 Mar 3. Proteins. 2017. PMID: 27936485

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