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Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways.
Lesniewski LA, Seals DR, Walker AE, Henson GD, Blimline MW, Trott DW, Bosshardt GC, LaRocca TJ, Lawson BR, Zigler MC, Donato AJ. Lesniewski LA, et al. Among authors: trott dw. Aging Cell. 2017 Feb;16(1):17-26. doi: 10.1111/acel.12524. Epub 2016 Sep 22. Aging Cell. 2017. PMID: 27660040 Free PMC article.
Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress.
Morgan RG, Walker AE, Trott DW, Machin DR, Henson GD, Reihl KD, Cawthon RM, Denchi EL, Liu Y, Bloom SI, Phuong TT, Richardson RS, Lesniewski LA, Donato AJ. Morgan RG, et al. Among authors: trott dw. J Mol Cell Cardiol. 2019 Feb;127:74-82. doi: 10.1016/j.yjmcc.2018.11.014. Epub 2018 Nov 29. J Mol Cell Cardiol. 2019. PMID: 30502348 Free PMC article.
T lymphocyte depletion ameliorates age-related metabolic impairments in mice.
Trott DW, Islam MT, Buckley DJ, Donato AJ, Dutson T, Sorensen ES, Cai J, Gogulamudi VR, Phuong TTT, Lesniewski LA. Trott DW, et al. Geroscience. 2021 Jun;43(3):1331-1347. doi: 10.1007/s11357-021-00368-4. Epub 2021 Apr 24. Geroscience. 2021. PMID: 33893902 Free PMC article.
T cells mediate cell non-autonomous arterial ageing in mice.
Trott DW, Machin DR, Phuong TTT, Adeyemo AO, Bloom SI, Bramwell RC, Sorensen ES, Lesniewski LA, Donato AJ. Trott DW, et al. J Physiol. 2021 Aug;599(16):3973-3991. doi: 10.1113/JP281698. J Physiol. 2021. PMID: 34164826 Free PMC article.
28 results