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Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways.
Lesniewski LA, Seals DR, Walker AE, Henson GD, Blimline MW, Trott DW, Bosshardt GC, LaRocca TJ, Lawson BR, Zigler MC, Donato AJ. Lesniewski LA, et al. Among authors: zigler mc. Aging Cell. 2017 Feb;16(1):17-26. doi: 10.1111/acel.12524. Epub 2016 Sep 22. Aging Cell. 2017. PMID: 27660040 Free PMC article.
Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice.
Brunt VE, Gioscia-Ryan RA, Richey JJ, Zigler MC, Cuevas LM, Gonzalez A, Vázquez-Baeza Y, Battson ML, Smithson AT, Gilley AD, Ackermann G, Neilson AP, Weir T, Davy KP, Knight R, Seals DR. Brunt VE, et al. Among authors: zigler mc. J Physiol. 2019 May;597(9):2361-2378. doi: 10.1113/JP277336. Epub 2019 Feb 27. J Physiol. 2019. PMID: 30714619 Free PMC article.
Short-term interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity, and whole-body glucose metabolism in old mice.
Ballak DB, Brunt VE, Sapinsley ZJ, Ziemba BP, Richey JJ, Zigler MC, Johnson LC, Gioscia-Ryan RA, Culp-Hill R, Eisenmesser EZ, D'Alessandro A, Dinarello CA, Seals DR. Ballak DB, et al. Among authors: zigler mc. Aging Cell. 2020 Jan;19(1):e13074. doi: 10.1111/acel.13074. Epub 2019 Nov 21. Aging Cell. 2020. PMID: 31755162 Free PMC article.
Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening.
Gioscia-Ryan RA, Clayton ZS, Fleenor BS, Eng JS, Johnson LC, Rossman MJ, Zigler MC, Evans TD, Seals DR. Gioscia-Ryan RA, et al. Among authors: zigler mc. Geroscience. 2021 Feb;43(1):423-432. doi: 10.1007/s11357-020-00212-1. Epub 2020 Jun 11. Geroscience. 2021. PMID: 32529594 Free PMC article.
Lifelong voluntary aerobic exercise prevents age- and Western diet- induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice.
Gioscia-Ryan RA, Clayton ZS, Zigler MC, Richey JJ, Cuevas LM, Rossman MJ, Battson ML, Ziemba BP, Hutton DA, VanDongen NS, Seals DR. Gioscia-Ryan RA, et al. Among authors: zigler mc. J Physiol. 2021 Feb;599(3):911-925. doi: 10.1113/JP280607. Epub 2020 Oct 28. J Physiol. 2021. PMID: 33103241 Free PMC article.
Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.
Brunt VE, Casso AG, Gioscia-Ryan RA, Sapinsley ZJ, Ziemba BP, Clayton ZS, Bazzoni AE, VanDongen NS, Richey JJ, Hutton DA, Zigler MC, Neilson AP, Davy KP, Seals DR. Brunt VE, et al. Among authors: zigler mc. Hypertension. 2021 Aug;78(2):499-511. doi: 10.1161/HYPERTENSIONAHA.120.16895. Epub 2021 May 10. Hypertension. 2021. PMID: 33966451 Free PMC article.
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