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PRL3-zumab, a first-in-class humanized antibody for cancer therapy.
Thura M, Al-Aidaroos AQO, Yong WP, Kono K, Gupta A, Lin YB, Mimura K, Thiery JP, Goh BC, Tan P, Soo R, Hong CW, Wang L, Lin SJ, Chen E, Rha SY, Chung HC, Li J, Nandi S, Yuen HF, Zhang SD, Guan YK, So J, Zeng Q. Thura M, et al. Among authors: al aidaroos aqo. JCI Insight. 2016 Jun 16;1(9):e87607. doi: 10.1172/jci.insight.87607. JCI Insight. 2016. PMID: 27699276 Free PMC article.
PRL-3 activates mTORC1 in Cancer Progression.
Ye Z, Al-Aidaroos AQ, Park JE, Yuen HF, Zhang SD, Gupta A, Lin Y, Shen HM, Zeng Q. Ye Z, et al. Sci Rep. 2015 Nov 24;5:17046. doi: 10.1038/srep17046. Sci Rep. 2015. PMID: 26597054 Free PMC article.
PRL1 and PRL3 promote macropinocytosis via its lipid phosphatase activity.
Ye Z, Ng CP, Liu H, Bao Q, Xu S, Zu D, He Y, Huang Y, Al-Aidaroos AQO, Guo K, Li J, Yaw LP, Xiong Q, Thura M, Zheng W, Guan F, Cheng X, Shi Y, Zeng Q. Ye Z, et al. Among authors: al aidaroos aqo. Theranostics. 2024 May 27;14(9):3423-3438. doi: 10.7150/thno.93127. eCollection 2024. Theranostics. 2024. PMID: 38948056 Free PMC article.
Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans.
Wang H, Liu B, Al-Aidaroos AQ, Shi H, Li L, Guo K, Li J, Tan BC, Loo JM, Tang JP, Thura M, Zeng Q. Wang H, et al. Oncogene. 2016 Jun 23;35(25):3303-13. doi: 10.1038/onc.2015.391. Epub 2015 Oct 12. Oncogene. 2016. PMID: 26455318 Free PMC article.
A role of autophagy in PTP4A3-driven cancer progression.
Huang YH, Al-Aidaroos AQ, Yuen HF, Zhang SD, Shen HM, Rozycka E, McCrudden CM, Tergaonkar V, Gupta A, Lin YB, Thiery JP, Murray JT, Zeng Q. Huang YH, et al. Autophagy. 2014 Oct 1;10(10):1787-800. doi: 10.4161/auto.29989. Epub 2014 Aug 1. Autophagy. 2014. PMID: 25136802 Free PMC article.
Oncogenic roles of PRL-3 in FLT3-ITD induced acute myeloid leukaemia.
Park JE, Yuen HF, Zhou JB, Al-Aidaroos AQ, Guo K, Valk PJ, Zhang SD, Chng WJ, Hong CW, Mills K, Zeng Q. Park JE, et al. EMBO Mol Med. 2013 Sep;5(9):1351-66. doi: 10.1002/emmm.201202183. Epub 2013 Aug 8. EMBO Mol Med. 2013. PMID: 23929599 Free PMC article.
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