MacKintosh C - Search Results

1

A Tbc1d1 ^Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice.

Chen Q, Xie B, Zhu S, Rong P, Sheng Y, Ducommun S, Chen L, Quan C, Li M, Sakamoto K, MacKintosh C, Chen S, Wang HY. Chen Q, et al. Among authors: mackintosh c. Diabetologia. 2017 Feb;60(2):336-345. doi: 10.1007/s00125-016-4151-9. Epub 2016 Nov 8. Diabetologia. 2017. PMID: 27826658

2

Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle.

Ducommun S, Wang HY, Sakamoto K, MacKintosh C, Chen S. Ducommun S, et al. Among authors: mackintosh c. Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1036-43. doi: 10.1152/ajpendo.00379.2011. Epub 2012 Feb 7. Am J Physiol Endocrinol Metab. 2012. PMID: 22318952 Free PMC article.

3

AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues.

Wang HY, Ducommun S, Quan C, Xie B, Li M, Wasserman DH, Sakamoto K, Mackintosh C, Chen S. Wang HY, et al. Among authors: mackintosh c. Biochem J. 2013 Jan 15;449(2):479-89. doi: 10.1042/BJ20120702. Biochem J. 2013. PMID: 23078342 Free PMC article.

4

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins.

Chen Q, Quan C, Xie B, Chen L, Zhou S, Toth R, Campbell DG, Lu S, Shirakawa R, Horiuchi H, Li C, Yang Z, MacKintosh C, Wang HY, Chen S. Chen Q, et al. Among authors: mackintosh c. Cell Signal. 2014 Aug;26(8):1636-48. doi: 10.1016/j.cellsig.2014.04.012. Epub 2014 Apr 24. Cell Signal. 2014. PMID: 24768767

5

Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.

Chen L, Chen Q, Xie B, Quan C, Sheng Y, Zhu S, Rong P, Zhou S, Sakamoto K, MacKintosh C, Wang HY, Chen S. Chen L, et al. Among authors: mackintosh c. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7219-24. doi: 10.1073/pnas.1600581113. Epub 2016 Jun 15. Proc Natl Acad Sci U S A. 2016. PMID: 27307439 Free PMC article.

6

Differential regulation of NHE1 phosphorylation and glucose uptake by inhibitors of the ERK pathway and p90RSK in 3T3-L1 adipocytes.

Chen S, Mackintosh C. Chen S, et al. Among authors: mackintosh c. Cell Signal. 2009 Dec;21(12):1984-93. doi: 10.1016/j.cellsig.2009.09.009. Epub 2009 Sep 15. Cell Signal. 2009. PMID: 19765648 Free article.

7

Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.

Chen S, Wasserman DH, MacKintosh C, Sakamoto K. Chen S, et al. Among authors: mackintosh c. Cell Metab. 2011 Jan 5;13(1):68-79. doi: 10.1016/j.cmet.2010.12.005. Cell Metab. 2011. PMID: 21195350 Free PMC article.

8

Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders.

Li M, Quan C, Toth R, Campbell DG, MacKintosh C, Wang HY, Chen S. Li M, et al. Among authors: mackintosh c. J Biol Chem. 2015 Dec 11;290(50):30030-41. doi: 10.1074/jbc.M115.668103. Epub 2015 Oct 23. J Biol Chem. 2015. PMID: 26499801 Free PMC article.

9

A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis.

Quan C, Du Q, Li M, Wang R, Ouyang Q, Su S, Zhu S, Chen Q, Sheng Y, Chen L, Wang H, Campbell DG, MacKintosh C, Yang Z, Ouyang K, Wang HY, Chen S. Quan C, et al. Among authors: mackintosh c. Nat Commun. 2020 May 4;11(1):2186. doi: 10.1038/s41467-020-16116-9. Nat Commun. 2020. PMID: 32367034 Free PMC article.

10

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.

Chen S, Murphy J, Toth R, Campbell DG, Morrice NA, Mackintosh C. Chen S, et al. Among authors: mackintosh c. Biochem J. 2008 Jan 15;409(2):449-59. doi: 10.1042/BJ20071114. Biochem J. 2008. PMID: 17995453

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