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Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders.
van Eunen K, Volker-Touw CM, Gerding A, Bleeker A, Wolters JC, van Rijt WJ, Martines AM, Niezen-Koning KE, Heiner RM, Permentier H, Groen AK, Reijngoud DJ, Derks TG, Bakker BM. van Eunen K, et al. Among authors: reijngoud dj. BMC Biol. 2016 Dec 7;14(1):107. doi: 10.1186/s12915-016-0327-5. BMC Biol. 2016. PMID: 27927213 Free PMC article.
Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload.
van Eunen K, Simons SM, Gerding A, Bleeker A, den Besten G, Touw CM, Houten SM, Groen BK, Krab K, Reijngoud DJ, Bakker BM. van Eunen K, et al. Among authors: reijngoud dj. PLoS Comput Biol. 2013;9(8):e1003186. doi: 10.1371/journal.pcbi.1003186. Epub 2013 Aug 15. PLoS Comput Biol. 2013. PMID: 23966849 Free PMC article.
Bistability in fatty-acid oxidation resulting from substrate inhibition.
Abegaz F, Martines AMF, Vieira-Lara MA, Rios-Morales M, Reijngoud DJ, Wit EC, Bakker BM. Abegaz F, et al. Among authors: reijngoud dj. PLoS Comput Biol. 2021 Aug 12;17(8):e1009259. doi: 10.1371/journal.pcbi.1009259. eCollection 2021 Aug. PLoS Comput Biol. 2021. PMID: 34383741 Free PMC article.
Risk stratification by residual enzyme activity after newborn screening for medium-chain acyl-CoA dehyrogenase deficiency: data from a cohort study.
Touw CM, Smit GP, de Vries M, de Klerk JB, Bosch AM, Visser G, Mulder MF, Rubio-Gozalbo ME, Elvers B, Niezen-Koning KE, Wanders RJ, Waterham HR, Reijngoud DJ, Derks TG. Touw CM, et al. Among authors: reijngoud dj. Orphanet J Rare Dis. 2012 May 25;7:30. doi: 10.1186/1750-1172-7-30. Orphanet J Rare Dis. 2012. PMID: 22630369 Free PMC article.
156 results