McDonald NQ - Search Results

1

RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.

Plaza-Menacho I, Barnouin K, Barry R, Borg A, Orme M, Chauhan R, Mouilleron S, Martínez-Torres RJ, Meier P, McDonald NQ. Plaza-Menacho I, et al. Among authors: mcdonald nq. Cell Rep. 2016 Dec 20;17(12):3319-3332. doi: 10.1016/j.celrep.2016.11.061. Cell Rep. 2016. PMID: 28009299 Free PMC article.

2

Structure and chemical inhibition of the RET tyrosine kinase domain.

Knowles PP, Murray-Rust J, Kjaer S, Scott RP, Hanrahan S, Santoro M, Ibáñez CF, McDonald NQ. Knowles PP, et al. Among authors: mcdonald nq. J Biol Chem. 2006 Nov 3;281(44):33577-87. doi: 10.1074/jbc.M605604200. Epub 2006 Aug 23. J Biol Chem. 2006. PMID: 16928683 Free article.

3

Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL.

Mouilleron S, Guettler S, Langer CA, Treisman R, McDonald NQ. Mouilleron S, et al. Among authors: mcdonald nq. EMBO J. 2008 Dec 3;27(23):3198-208. doi: 10.1038/emboj.2008.235. Epub 2008 Nov 13. EMBO J. 2008. PMID: 19008859 Free PMC article.

4

Focal adhesion kinase (FAK) binds RET kinase via its FERM domain, priming a direct and reciprocal RET-FAK transactivation mechanism.

Plaza-Menacho I, Morandi A, Mologni L, Boender P, Gambacorti-Passerini C, Magee AI, Hofstra RM, Knowles P, McDonald NQ, Isacke CM. Plaza-Menacho I, et al. Among authors: mcdonald nq. J Biol Chem. 2011 May 13;286(19):17292-302. doi: 10.1074/jbc.M110.168500. Epub 2011 Mar 22. J Biol Chem. 2011. PMID: 21454698 Free PMC article.

5

Structure of a pentavalent G-actin*MRTF-A complex reveals how G-actin controls nucleocytoplasmic shuttling of a transcriptional coactivator.

Mouilleron S, Langer CA, Guettler S, McDonald NQ, Treisman R. Mouilleron S, et al. Among authors: mcdonald nq. Sci Signal. 2011 Jun 14;4(177):ra40. doi: 10.1126/scisignal.2001750. Sci Signal. 2011. PMID: 21673315

6

Fluorescence-based incision assay for human XPF-ERCC1 activity identifies important elements of DNA junction recognition.

Bowles M, Lally J, Fadden AJ, Mouilleron S, Hammonds T, McDonald NQ. Bowles M, et al. Among authors: mcdonald nq. Nucleic Acids Res. 2012 Jul;40(13):e101. doi: 10.1093/nar/gks284. Epub 2012 Mar 28. Nucleic Acids Res. 2012. PMID: 22457069 Free PMC article.

7

G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly.

Wiezlak M, Diring J, Abella J, Mouilleron S, Way M, McDonald NQ, Treisman R. Wiezlak M, et al. Among authors: mcdonald nq. J Cell Sci. 2012 Dec 1;125(Pt 23):5860-72. doi: 10.1242/jcs.112078. Epub 2012 Sep 12. J Cell Sci. 2012. PMID: 22976292

8

Structures of the Phactr1 RPEL domain and RPEL motif complexes with G-actin reveal the molecular basis for actin binding cooperativity.

Mouilleron S, Wiezlak M, O'Reilly N, Treisman R, McDonald NQ. Mouilleron S, et al. Among authors: mcdonald nq. Structure. 2012 Nov 7;20(11):1960-70. doi: 10.1016/j.str.2012.08.031. Epub 2012 Oct 4. Structure. 2012. PMID: 23041370 Free article.

9

Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans.

Plaza-Menacho I, Barnouin K, Goodman K, Martínez-Torres RJ, Borg A, Murray-Rust J, Mouilleron S, Knowles P, McDonald NQ. Plaza-Menacho I, et al. Among authors: mcdonald nq. Mol Cell. 2014 Mar 6;53(5):738-51. doi: 10.1016/j.molcel.2014.01.015. Epub 2014 Feb 20. Mol Cell. 2014. PMID: 24560924 Free PMC article.

10

Mechanisms of RET signaling in cancer: current and future implications for targeted therapy.

Plaza-Menacho I, Mologni L, McDonald NQ. Plaza-Menacho I, et al. Among authors: mcdonald nq. Cell Signal. 2014 Aug;26(8):1743-52. doi: 10.1016/j.cellsig.2014.03.032. Epub 2014 Apr 3. Cell Signal. 2014. PMID: 24705026 Review.

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