Donnelly D - Search Results

1

High affinity binding of the peptide agonist TIP-39 to the parathyroid hormone 2 (PTH₂) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.

Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, Donnelly D. Weaver RE, et al. Among authors: donnelly d. Biochem Pharmacol. 2017 Mar 1;127:71-81. doi: 10.1016/j.bcp.2016.12.013. Epub 2016 Dec 22. Biochem Pharmacol. 2017. PMID: 28012961 Free PMC article.

2

Ligand-receptor interactions at the parathyroid hormone receptors: subtype binding selectivity is mediated via an interaction between residue 23 on the ligand and residue 41 on the receptor.

Mann R, Wigglesworth MJ, Donnelly D. Mann R, et al. Among authors: donnelly d. Mol Pharmacol. 2008 Sep;74(3):605-13. doi: 10.1124/mol.108.048017. Epub 2008 Jun 6. Mol Pharmacol. 2008. PMID: 18539702

3

A salt bridge between Arg-20 on parathyroid hormone (PTH) and Asp-137 on the PTH1 receptor is essential for full affinity.

Weaver RE, Wigglesworth MJ, Donnelly D. Weaver RE, et al. Among authors: donnelly d. Peptides. 2014 Nov;61:83-7. doi: 10.1016/j.peptides.2014.09.004. Epub 2014 Sep 13. Peptides. 2014. PMID: 25218037

4

Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.

Miller PS, Barwell J, Poyner DR, Wigglesworth MJ, Garland SL, Donnelly D. Miller PS, et al. Among authors: donnelly d. Biochem Biophys Res Commun. 2010 Jan 1;391(1):437-42. doi: 10.1016/j.bbrc.2009.11.076. Epub 2009 Nov 13. Biochem Biophys Res Commun. 2010. PMID: 19914210 Free PMC article.

5

Functional expression of glucose-dependent insulinotropic polypeptide receptors is coupled to differentiation in a human adipocyte model.

Weaver RE, Donnelly D, Wabitsch M, Grant PJ, Balmforth AJ. Weaver RE, et al. Among authors: donnelly d. Int J Obes (Lond). 2008 Nov;32(11):1705-11. doi: 10.1038/ijo.2008.148. Epub 2008 Sep 9. Int J Obes (Lond). 2008. PMID: 18779825

6

Conformational induction is the key process for activation of the AT1 receptor.

Ellis J, Warburton P, Donnelly D, Balmforth AJ. Ellis J, et al. Among authors: donnelly d. Biochem Pharmacol. 2006 Feb 14;71(4):464-71. doi: 10.1016/j.bcp.2005.11.011. Epub 2005 Dec 15. Biochem Pharmacol. 2006. PMID: 16343447

7

A mechanism for agonist activation of the glucagon-like peptide-1 (GLP-1) receptor through modelling & molecular dynamics.

Gómez Santiago C, Paci E, Donnelly D. Gómez Santiago C, et al. Among authors: donnelly d. Biochem Biophys Res Commun. 2018 Mar 29;498(2):359-365. doi: 10.1016/j.bbrc.2018.01.110. Epub 2018 Feb 12. Biochem Biophys Res Commun. 2018. PMID: 29397068 Free article.

8

Peptide binding at the GLP-1 receptor.

Mann R, Nasr N, Hadden D, Sinfield J, Abidi F, Al-Sabah S, de Maturana RL, Treece-Birch J, Willshaw A, Donnelly D. Mann R, et al. Among authors: donnelly d. Biochem Soc Trans. 2007 Aug;35(Pt 4):713-6. doi: 10.1042/BST0350713. Biochem Soc Trans. 2007. PMID: 17635131 Review.

9

Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications.

Donnelly D, Maudsley S, Gent JP, Moser RN, Hurrell CR, Findlay JB. Donnelly D, et al. Biochem J. 1999 Apr 1;339 ( Pt 1)(Pt 1):55-61. Biochem J. 1999. PMID: 10085227 Free PMC article.

10

The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4.

Mann RJ, Nasr NE, Sinfield JK, Paci E, Donnelly D. Mann RJ, et al. Among authors: donnelly d. Br J Pharmacol. 2010 Aug;160(8):1973-84. doi: 10.1111/j.1476-5381.2010.00834.x. Br J Pharmacol. 2010. PMID: 20649595 Free PMC article.

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