Otieno MA - Search Results

1

Mechanisms for Hepatobiliary Toxicity in Rats Treated with an Antagonist of Melanin Concentrating Hormone Receptor 1 (MCHR1).

Otieno MA, Bhaskaran V, Janovitz E, Callejas Y, Foster WB, Washburn W, Megill JR, Lehman-McKeeman L, Gemzik B. Otieno MA, et al. Toxicol Sci. 2017 Feb;155(2):379-388. doi: 10.1093/toxsci/kfw216. Epub 2016 Oct 20. Toxicol Sci. 2017. PMID: 28025230

2

Evaluation and validation of multiple cell lines and primary mouse macrophages to predict phospholipidosis potential.

LeCureux L, Cheng CS, Herbst J, Reilly TP, Lehman-McKeeman L, Otieno M. LeCureux L, et al. Toxicol In Vitro. 2011 Dec;25(8):1934-43. doi: 10.1016/j.tiv.2011.06.017. Epub 2011 Jul 13. Toxicol In Vitro. 2011. PMID: 21767630

3

Beyond miR-122: Identification of MicroRNA Alterations in Blood During a Time Course of Hepatobiliary Injury and Biliary Hyperplasia in Rats.

Church RJ, Otieno M, McDuffie JE, Singh B, Sonee M, Hall L, Watkins PB, Ellinger-Ziegelbauer H, Harrill AH. Church RJ, et al. Toxicol Sci. 2016 Mar;150(1):3-14. doi: 10.1093/toxsci/kfv260. Epub 2015 Nov 26. Toxicol Sci. 2016. PMID: 26614776 Free PMC article.

4

Mechanistic investigation of N,N-diethyl-4-(phenyl-piperidin-4-ylidenemethyl)-benzamide-induced insulin depletion in the rat and RINm5F cells.

Otieno MA, Bavuso N, Milano J, Foster-Brown L, Bui KH, Li Y, Hudzik T, Wescott D, Louden C, Dyroff M, Pognan F. Otieno MA, et al. Toxicol Sci. 2008 Sep;105(1):221-9. doi: 10.1093/toxsci/kfn108. Epub 2008 Jun 6. Toxicol Sci. 2008. PMID: 18539914

5

Fasiglifam (TAK-875): Mechanistic Investigation and Retrospective Identification of Hazards for Drug Induced Liver Injury.

Otieno MA, Snoeys J, Lam W, Ghosh A, Player MR, Pocai A, Salter R, Simic D, Skaggs H, Singh B, Lim HK. Otieno MA, et al. Toxicol Sci. 2018 Jun 1;163(2):374-384. doi: 10.1093/toxsci/kfx040. Toxicol Sci. 2018. PMID: 28206647

6

Hepatocyte-Derived Exosomes Promote Liver Immune Tolerance: Possible Implications for Idiosyncratic Drug-Induced Liver Injury.

Holman NS, Church RJ, Nautiyal M, Rose KA, Thacker SE, Otieno MA, Wolf KK, LeCluyse E, Watkins PB, Mosedale M. Holman NS, et al. Among authors: otieno ma. Toxicol Sci. 2019 Aug 1;170(2):499-508. doi: 10.1093/toxsci/kfz112. Toxicol Sci. 2019. PMID: 31093666 Free PMC article.

7

Optimized Methods to Explore the Mechanistic and Biomarker Potential of Hepatocyte-Derived Exosomes in Drug-Induced Liver Injury.

Thacker SE, Nautiyal M, Otieno MA, Watkins PB, Mosedale M. Thacker SE, et al. Among authors: otieno ma. Toxicol Sci. 2018 May 1;163(1):92-100. doi: 10.1093/toxsci/kfy015. Toxicol Sci. 2018. PMID: 29385596

8

Reproducing human and cross-species drug toxicities using a Liver-Chip.

Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, Petropolis DB, Kulkarni G, Rubins JE, Conegliano D, Nawroth J, Simic D, Lam W, Singer M, Barale E, Singh B, Sonee M, Streeter AJ, Manthey C, Jones B, Srivastava A, Andersson LC, Williams D, Park H, Barrile R, Sliz J, Herland A, Haney S, Karalis K, Ingber DE, Hamilton GA. Jang KJ, et al. Among authors: otieno ma. Sci Transl Med. 2019 Nov 6;11(517):eaax5516. doi: 10.1126/scitranslmed.aax5516. Sci Transl Med. 2019. PMID: 31694927

9

Discovery of novel benzo[b]thiophene tetrazoles as non-carboxylate GPR40 agonists.

Huang H, Winters MP, Meegalla SK, Arnoult E, Paul Lee S, Zhao S, Martin T, Rady B, Liu J, Towers M, Otieno M, Xu F, Lim HK, Silva J, Pocai A, Player MR. Huang H, et al. Bioorg Med Chem Lett. 2018 Feb 1;28(3):429-436. doi: 10.1016/j.bmcl.2017.12.022. Epub 2017 Dec 12. Bioorg Med Chem Lett. 2018. PMID: 29258772

10

Discovery of a novel potent GPR40 full agonist.

Meegalla SK, Huang H, Martin T, Xu J, Zhao S, Liu J, Hall M, Gunnet J, Wang Y, Rady B, Silva J, Otieno M, Arnoult E, Paul Lee S, Pocai A, Player MR. Meegalla SK, et al. Bioorg Med Chem Lett. 2018 Feb 15;28(4):720-726. doi: 10.1016/j.bmcl.2018.01.013. Epub 2018 Jan 12. Bioorg Med Chem Lett. 2018. PMID: 29366647

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