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Sensitive Versatile Fluorogenic Transmembrane Peptide Substrates for Rhomboid Intramembrane Proteases.
Tichá A, Stanchev S, Škerle J, Began J, Ingr M, Švehlová K, Polovinkin L, Růžička M, Bednárová L, Hadravová R, Poláchová E, Rampírová P, Březinová J, Kašička V, Majer P, Strisovsky K. Tichá A, et al. J Biol Chem. 2017 Feb 17;292(7):2703-2713. doi: 10.1074/jbc.M116.762849. Epub 2017 Jan 9. J Biol Chem. 2017. PMID: 28069810 Free PMC article.
General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases.
Tichá A, Stanchev S, Vinothkumar KR, Mikles DC, Pachl P, Began J, Škerle J, Švehlová K, Nguyen MTN, Verhelst SHL, Johnson DC, Bachovchin DA, Lepšík M, Majer P, Strisovsky K. Tichá A, et al. Cell Chem Biol. 2017 Dec 21;24(12):1523-1536.e4. doi: 10.1016/j.chembiol.2017.09.007. Epub 2017 Oct 26. Cell Chem Biol. 2017. PMID: 29107700 Free PMC article.
Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases.
Goel P, Jumpertz T, Mikles DC, Tichá A, Nguyen MTN, Verhelst S, Hubalek M, Johnson DC, Bachovchin DA, Ogorek I, Pietrzik CU, Strisovsky K, Schmidt B, Weggen S. Goel P, et al. Among authors: ticha a. Biochemistry. 2017 Dec 26;56(51):6713-6725. doi: 10.1021/acs.biochem.7b01066. Epub 2017 Dec 12. Biochemistry. 2017. PMID: 29185711 Free PMC article.
Novel lipidized analogs of prolactin-releasing peptide have prolonged half-lives and exert anti-obesity effects after peripheral administration.
Maletínská L, Nagelová V, Tichá A, Zemenová J, Pirník Z, Holubová M, Špolcová A, Mikulášková B, Blechová M, Sýkora D, Lacinová Z, Haluzík M, Železná B, Kuneš J. Maletínská L, et al. Among authors: ticha a. Int J Obes (Lond). 2015 Jun;39(6):986-93. doi: 10.1038/ijo.2015.28. Epub 2015 Mar 16. Int J Obes (Lond). 2015. PMID: 25771926
69 results