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GroEL/ES inhibitors as potential antibiotics.
Abdeen S, Salim N, Mammadova N, Summers CM, Frankson R, Ambrose AJ, Anderson GG, Schultz PG, Horwich AL, Chapman E, Johnson SM. Abdeen S, et al. Among authors: ambrose aj. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3127-3134. doi: 10.1016/j.bmcl.2016.04.089. Epub 2016 May 4. Bioorg Med Chem Lett. 2016. PMID: 27184767 Free article.
Arsenic Compromises Both p97 and Proteasome Functions.
Tillotson J, Zerio CJ, Harder B, Ambrose AJ, Jung KS, Kang M, Zhang DD, Chapman E. Tillotson J, et al. Among authors: ambrose aj. Chem Res Toxicol. 2017 Jul 17;30(7):1508-1514. doi: 10.1021/acs.chemrestox.7b00158. Epub 2017 Jul 7. Chem Res Toxicol. 2017. PMID: 28636814 Free PMC article.
ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A.
Tillotson J, Kedzior M, Guimarães L, Ross AB, Peters TL, Ambrose AJ, Schmidlin CJ, Zhang DD, Costa-Lotufo LV, Rodríguez AD, Schatz JH, Chapman E. Tillotson J, et al. Among authors: ambrose aj. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4082-4085. doi: 10.1016/j.bmcl.2017.07.045. Epub 2017 Jul 19. Bioorg Med Chem Lett. 2017. PMID: 28757063 Free PMC article.
Increased O-GlcNAcylation of SNAP29 Drives Arsenic-Induced Autophagic Dysfunction.
Dodson M, Liu P, Jiang T, Ambrose AJ, Luo G, Rojo de la Vega M, Cholanians AB, Wong PK, Chapman E, Zhang DD. Dodson M, et al. Among authors: ambrose aj. Mol Cell Biol. 2018 May 15;38(11):e00595-17. doi: 10.1128/MCB.00595-17. Print 2018 Jun 1. Mol Cell Biol. 2018. PMID: 29507186 Free PMC article.
Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity.
Peters TL, Tillotson J, Yeomans AM, Wilmore S, Lemm E, Jiménez-Romero C, Amador LA, Li L, Amin AD, Pongtornpipat P, Zerio CJ, Ambrose AJ, Paine-Murrieta G, Greninger P, Vega F, Benes CH, Packham G, Rodríguez AD, Chapman E, Schatz JH. Peters TL, et al. Among authors: ambrose aj. Clin Cancer Res. 2018 Sep 1;24(17):4256-4270. doi: 10.1158/1078-0432.CCR-17-3645. Epub 2018 May 29. Clin Cancer Res. 2018. PMID: 29844128 Free PMC article.
Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA).
Abdeen S, Kunkle T, Salim N, Ray AM, Mammadova N, Summers C, Stevens M, Ambrose AJ, Park Y, Schultz PG, Horwich AL, Hoang QQ, Chapman E, Johnson SM. Abdeen S, et al. Among authors: ambrose aj. J Med Chem. 2018 Aug 23;61(16):7345-7357. doi: 10.1021/acs.jmedchem.8b00989. Epub 2018 Aug 14. J Med Chem. 2018. PMID: 30060666 Free PMC article.
42 results