The saturation degree of fatty acids and their derived acylcarnitines determines the direct effect of metabolically active thyroid hormones on insulin sensitivity in skeletal muscle cells.
Giacco A, Delli Paoli G, Senese R, Cioffi F, Silvestri E, Moreno M, Ruoppolo M, Caterino M, Costanzo M, Lombardi A, Goglia F, Lanni A, de Lange P.
Giacco A, et al.
FASEB J. 2019 Feb;33(2):1811-1823. doi: 10.1096/fj.201800724R. Epub 2018 Sep 11.
FASEB J. 2019.
PMID: 30204501
Using differentiated rat L6 cells, we studied the direct effect of 3,5,3'-triiodo-l-thyronine (T3) and 3,5-diiodo-l-thyronine (T2) on the response to insulin in presence of fatty acids with a varying degree of saturation. We found that T3 and T2 both invert the response to …
Using differentiated rat L6 cells, we studied the direct effect of 3,5,3'-triiodo-l-thyronine (T3) and 3,5-diiodo-l-thyronine (T2) on the re …