Xu W - Search Results

1

Stabilizing short-lived Schiff base derivatives of 5-aminouracils that activate mucosal-associated invariant T cells.

Mak JY, Xu W, Reid RC, Corbett AJ, Meehan BS, Wang H, Chen Z, Rossjohn J, McCluskey J, Liu L, Fairlie DP. Mak JY, et al. Among authors: xu w. Nat Commun. 2017 Mar 8;8:14599. doi: 10.1038/ncomms14599. Nat Commun. 2017. PMID: 28272391 Free PMC article.

2

Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.

Keller AN, Eckle SB, Xu W, Liu L, Hughes VA, Mak JY, Meehan BS, Pediongco T, Birkinshaw RW, Chen Z, Wang H, D'Souza C, Kjer-Nielsen L, Gherardin NA, Godfrey DI, Kostenko L, Corbett AJ, Purcell AW, Fairlie DP, McCluskey J, Rossjohn J. Keller AN, et al. Among authors: xu w. Nat Immunol. 2017 Apr;18(4):402-411. doi: 10.1038/ni.3679. Epub 2017 Feb 6. Nat Immunol. 2017. PMID: 28166217

3

Computer Modelling and Synthesis of Deoxy and Monohydroxy Analogues of a Ribitylaminouracil Bacterial Metabolite that Potently Activates Human T Cells.

Ler GJM, Xu W, Mak JYW, Liu L, Bernhardt PV, Fairlie DP. Ler GJM, et al. Among authors: xu w. Chemistry. 2019 Dec 5;25(68):15594-15608. doi: 10.1002/chem.201903732. Epub 2019 Nov 7. Chemistry. 2019. PMID: 31529537

4

The molecular basis underpinning the potency and specificity of MAIT cell antigens.

Awad W, Ler GJM, Xu W, Keller AN, Mak JYW, Lim XY, Liu L, Eckle SBG, Le Nours J, McCluskey J, Corbett AJ, Fairlie DP, Rossjohn J. Awad W, et al. Among authors: xu w. Nat Immunol. 2020 Apr;21(4):400-411. doi: 10.1038/s41590-020-0616-6. Epub 2020 Mar 2. Nat Immunol. 2020. PMID: 32123373

5

Chemical Approaches to Modulating Complement-Mediated Diseases.

Iyer A, Xu W, Reid RC, Fairlie DP. Iyer A, et al. Among authors: xu w. J Med Chem. 2018 Apr 26;61(8):3253-3276. doi: 10.1021/acs.jmedchem.7b00882. Epub 2017 Oct 18. J Med Chem. 2018. PMID: 28977749 Review.

6

Potent Small Agonists of Protease Activated Receptor 2.

Yau MK, Suen JY, Xu W, Lim J, Liu L, Adams MN, He Y, Hooper JD, Reid RC, Fairlie DP. Yau MK, et al. Among authors: xu w. ACS Med Chem Lett. 2015 Nov 30;7(1):105-10. doi: 10.1021/acsmedchemlett.5b00429. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819675 Free PMC article.

7

Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell Proliferation.

Tng J, Lim J, Wu KC, Lucke AJ, Xu W, Reid RC, Fairlie DP. Tng J, et al. Among authors: xu w. J Med Chem. 2020 Jun 11;63(11):5956-5971. doi: 10.1021/acs.jmedchem.0c00230. Epub 2020 May 21. J Med Chem. 2020. PMID: 32383881

8

Comparing sixteen scoring functions for predicting biological activities of ligands for protein targets.

Xu W, Lucke AJ, Fairlie DP. Xu W, et al. J Mol Graph Model. 2015 Apr;57:76-88. doi: 10.1016/j.jmgm.2015.01.009. Epub 2015 Feb 1. J Mol Graph Model. 2015. PMID: 25682361

9

Repurposing Registered Drugs as Antagonists for Protease-Activated Receptor 2.

Xu W, Lim J, Goh CY, Suen JY, Jiang Y, Yau MK, Wu KC, Liu L, Fairlie DP. Xu W, et al. J Chem Inf Model. 2015 Oct 26;55(10):2079-84. doi: 10.1021/acs.jcim.5b00500. Epub 2015 Oct 12. J Chem Inf Model. 2015. PMID: 26445028

10

Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.

Seow V, Lim J, Cotterell AJ, Yau MK, Xu W, Lohman RJ, Kok WM, Stoermer MJ, Sweet MJ, Reid RC, Suen JY, Fairlie DP. Seow V, et al. Among authors: xu w. Sci Rep. 2016 Apr 20;6:24575. doi: 10.1038/srep24575. Sci Rep. 2016. PMID: 27094554 Free PMC article.

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