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Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.
Leroy J, Richter W, Mika D, Castro LR, Abi-Gerges A, Xie M, Scheitrum C, Lefebvre F, Schittl J, Mateo P, Westenbroek R, Catterall WA, Charpentier F, Conti M, Fischmeister R, Vandecasteele G. Leroy J, et al. Among authors: vandecasteele g. J Clin Invest. 2011 Jul;121(7):2651-61. doi: 10.1172/JCI44747. Epub 2011 Jun 13. J Clin Invest. 2011. PMID: 21670503 Free PMC article.
PDEs create local domains of cAMP signaling.
Mika D, Leroy J, Vandecasteele G, Fischmeister R. Mika D, et al. Among authors: vandecasteele g. J Mol Cell Cardiol. 2012 Feb;52(2):323-9. doi: 10.1016/j.yjmcc.2011.08.016. Epub 2011 Aug 23. J Mol Cell Cardiol. 2012. PMID: 21888909 Review.
Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Mehel H, et al. Among authors: vandecasteele g. J Am Coll Cardiol. 2013 Oct 22;62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26. J Am Coll Cardiol. 2013. PMID: 23810893 Free article.
64 results