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Page 1
Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity.
Jayakody T, Marwari S, Lakshminarayanan R, Tan FC, Johannes CW, Dymock BW, Poulsen A, Herr DR, Dawe GS. Jayakody T, et al. Among authors: johannes cw. Peptides. 2016 Oct;84:44-57. doi: 10.1016/j.peptides.2016.08.001. Epub 2016 Aug 3. Peptides. 2016. PMID: 27498038 Free article.
Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.
Sawyer TK, Partridge AW, Kaan HYK, Juang YC, Lim S, Johannes C, Yuen TY, Verma C, Kannan S, Aronica P, Tan YS, Sherborne B, Ha S, Hochman J, Chen S, Surdi L, Peier A, Sauvagnat B, Dandliker PJ, Brown CJ, Ng S, Ferrer F, Lane DP. Sawyer TK, et al. Bioorg Med Chem. 2018 Jun 1;26(10):2807-2815. doi: 10.1016/j.bmc.2018.03.008. Epub 2018 Mar 16. Bioorg Med Chem. 2018. PMID: 29598901
Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties.
Partridge AW, Kaan HYK, Juang YC, Sadruddin A, Lim S, Brown CJ, Ng S, Thean D, Ferrer F, Johannes C, Yuen TY, Kannan S, Aronica P, Tan YS, Pradhan MR, Verma CS, Hochman J, Chen S, Wan H, Ha S, Sherborne B, Lane DP, Sawyer TK. Partridge AW, et al. Molecules. 2019 Jun 20;24(12):2292. doi: 10.3390/molecules24122292. Molecules. 2019. PMID: 31226791 Free PMC article.
Examining Immunotherapy Response Using Multiple Radiotracers.
Goggi JL, Hartimath SV, Hwang Y, Tan YX, Khanapur S, Ramasamy B, Jiang L, Yong FF, Cheng P, Tan PW, Husaini MA, Yuen TY, Jieu B, Chacko AM, Larbi A, Renia L, Johannes C, Robins EG. Goggi JL, et al. Mol Imaging Biol. 2020 Aug;22(4):993-1002. doi: 10.1007/s11307-020-01477-w. Mol Imaging Biol. 2020. PMID: 32006204
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA).
Lim S, Khoo R, Peh KM, Teo J, Chang SC, Ng S, Beilhartz GL, Melnyk RA, Johannes CW, Brown CJ, Lane DP, Henry B, Partridge AW. Lim S, et al. Among authors: johannes cw. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):5791-5800. doi: 10.1073/pnas.1920251117. Epub 2020 Mar 2. Proc Natl Acad Sci U S A. 2020. PMID: 32123106 Free PMC article.
Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability.
Kannan S, Aronica PGA, Ng S, Gek Lian DT, Frosi Y, Chee S, Shimin J, Yuen TY, Sadruddin A, Kaan HYK, Chandramohan A, Wong JH, Tan YS, Chang ZW, Ferrer-Gago FJ, Arumugam P, Han Y, Chen S, Rénia L, Brown CJ, Johannes CW, Henry B, Lane DP, Sawyer TK, Verma CS, Partridge AW. Kannan S, et al. Among authors: johannes cw. Chem Sci. 2020 May 11;11(21):5577-5591. doi: 10.1039/c9sc06383h. eCollection 2020 Jun 7. Chem Sci. 2020. PMID: 32874502 Free PMC article.
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