Humphreys WG - Search Results

1

Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.

Cheng Y, Chen S, Freeden C, Chen W, Zhang Y, Abraham P, Nelson DM, Humphreys WG, Gan J, Lai Y. Cheng Y, et al. Among authors: humphreys wg. J Pharmacol Exp Ther. 2017 Sep;362(3):385-394. doi: 10.1124/jpet.117.242370. Epub 2017 Jun 23. J Pharmacol Exp Ther. 2017. PMID: 28645914

2

Dansyl glutathione as a trapping agent for the quantitative estimation and identification of reactive metabolites.

Gan J, Harper TW, Hsueh MM, Qu Q, Humphreys WG. Gan J, et al. Among authors: humphreys wg. Chem Res Toxicol. 2005 May;18(5):896-903. doi: 10.1021/tx0496791. Chem Res Toxicol. 2005. PMID: 15892584

3

CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183).

Zhang D, Ly VT, Lago M, Tian Y, Gan J, Humphreys WG, Cömezoglu SN. Zhang D, et al. Among authors: humphreys wg. Drug Metab Dispos. 2009 Apr;37(4):710-8. doi: 10.1124/dmd.108.024398. Epub 2009 Jan 21. Drug Metab Dispos. 2009. PMID: 19158314

4

In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.

Gan J, Ruan Q, He B, Zhu M, Shyu WC, Humphreys WG. Gan J, et al. Among authors: humphreys wg. Chem Res Toxicol. 2009 Apr;22(4):690-8. doi: 10.1021/tx800368n. Chem Res Toxicol. 2009. PMID: 19253935

5

Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS).

Cömezoğlu SN, Ly VT, Zhang D, Humphreys WG, Bonacorsi SJ, Everett DW, Cohen MB, Gan J, Beumer JH, Beijnen JH, Schellens HM, Lappin G. Cömezoğlu SN, et al. Among authors: humphreys wg. Drug Metab Pharmacokinet. 2009;24(6):511-22. doi: 10.2133/dmpk.24.511. Drug Metab Pharmacokinet. 2009. PMID: 20045986 Free article.

6

Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism.

Gan J, Chen W, Shen H, Gao L, Hong Y, Tian Y, Li W, Zhang Y, Tang Y, Zhang H, Humphreys WG, Rodrigues AD. Gan J, et al. Among authors: humphreys wg. Br J Clin Pharmacol. 2010 Dec;70(6):870-80. doi: 10.1111/j.1365-2125.2010.03772.x. Br J Clin Pharmacol. 2010. PMID: 21175442 Free PMC article.

7

Bioactivation of substituted thiophenes including α-chlorothiophene-containing compounds in human liver microsomes.

Chen W, Caceres-Cortes J, Zhang H, Zhang D, Humphreys WG, Gan J. Chen W, et al. Among authors: humphreys wg. Chem Res Toxicol. 2011 May 16;24(5):663-9. doi: 10.1021/tx100386z. Epub 2011 Apr 13. Chem Res Toxicol. 2011. PMID: 21417487

8

In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin.

Gan J, Liu-Kreyche P, Humphreys WG. Gan J, et al. Among authors: humphreys wg. Cancer Chemother Pharmacol. 2012 Jan;69(1):51-6. doi: 10.1007/s00280-011-1672-2. Epub 2011 May 19. Cancer Chemother Pharmacol. 2012. PMID: 21594721

9

Cytochrome P450 11A1 bioactivation of a kinase inhibitor in rats: use of radioprofiling, modulation of metabolism, and adrenocortical cell lines to evaluate adrenal toxicity.

Zhang D, Flint O, Wang L, Gupta A, Westhouse RA, Zhao W, Raghavan N, Caceres-Cortes J, Marathe P, Shen G, Zhang Y, Allentoff A, Josephs J, Gan J, Borzilleri R, Humphreys WG. Zhang D, et al. Among authors: humphreys wg. Chem Res Toxicol. 2012 Mar 19;25(3):556-71. doi: 10.1021/tx200524d. Epub 2012 Mar 2. Chem Res Toxicol. 2012. PMID: 22295996

10

Characterization of efflux transporters involved in distribution and disposition of apixaban.

Zhang D, He K, Herbst JJ, Kolb J, Shou W, Wang L, Balimane PV, Han YH, Gan J, Frost CE, Humphreys WG. Zhang D, et al. Among authors: humphreys wg. Drug Metab Dispos. 2013 Apr;41(4):827-35. doi: 10.1124/dmd.112.050260. Epub 2013 Feb 4. Drug Metab Dispos. 2013. PMID: 23382458

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