Lai Y - Search Results

1

Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.

Cheng Y, Chen S, Freeden C, Chen W, Zhang Y, Abraham P, Nelson DM, Humphreys WG, Gan J, Lai Y. Cheng Y, et al. Among authors: lai y. J Pharmacol Exp Ther. 2017 Sep;362(3):385-394. doi: 10.1124/jpet.117.242370. Epub 2017 Jun 23. J Pharmacol Exp Ther. 2017. PMID: 28645914

2

Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump.

Rodrigues AD, Lai Y, Cvijic ME, Elkin LL, Zvyaga T, Soars MG. Rodrigues AD, et al. Among authors: lai y. Drug Metab Dispos. 2014 Apr;42(4):566-74. doi: 10.1124/dmd.113.054205. Epub 2013 Oct 10. Drug Metab Dispos. 2014. PMID: 24115749 Review.

3

Evaluation of rosuvastatin as an organic anion transporting polypeptide (OATP) probe substrate: in vitro transport and in vivo disposition in cynomolgus monkeys.

Shen H, Su H, Liu T, Yao M, Mintier G, Li L, Fancher RM, Iyer R, Marathe P, Lai Y, Rodrigues AD. Shen H, et al. Among authors: lai y. J Pharmacol Exp Ther. 2015 May;353(2):380-91. doi: 10.1124/jpet.114.221804. Epub 2015 Mar 4. J Pharmacol Exp Ther. 2015. PMID: 25740896

4

Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.

Shen H, Liu T, Morse BL, Zhao Y, Zhang Y, Qiu X, Chen C, Lewin AC, Wang XT, Liu G, Christopher LJ, Marathe P, Lai Y. Shen H, et al. Among authors: lai y. Drug Metab Dispos. 2015 Jul;43(7):984-93. doi: 10.1124/dmd.114.062364. Epub 2015 Apr 22. Drug Metab Dispos. 2015. PMID: 25904762

5

Rosuvastatin Liver Partitioning in Cynomolgus Monkeys: Measurement In Vivo and Prediction Using In Vitro Monkey Hepatocyte Uptake.

Morse BL, Cai H, MacGuire JG, Fox M, Zhang L, Zhang Y, Gu X, Shen H, Dierks EA, Su H, Luk CE, Marathe P, Shu YZ, Humphreys WG, Lai Y. Morse BL, et al. Among authors: lai y. Drug Metab Dispos. 2015 Nov;43(11):1788-94. doi: 10.1124/dmd.115.065946. Epub 2015 Sep 4. Drug Metab Dispos. 2015. PMID: 26341276

6

Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.

Zhang Y, Han YH, Putluru SP, Matta MK, Kole P, Mandlekar S, Furlong MT, Liu T, Iyer RA, Marathe P, Yang Z, Lai Y, Rodrigues AD. Zhang Y, et al. Among authors: lai y. Drug Metab Dispos. 2016 Mar;44(3):320-8. doi: 10.1124/dmd.115.066944. Epub 2015 Dec 29. Drug Metab Dispos. 2016. PMID: 26714763

7

Involvement of Drug Transporters in Organ Toxicity: The Fundamental Basis of Drug Discovery and Development.

Cheng Y, El-Kattan A, Zhang Y, Ray AS, Lai Y. Cheng Y, et al. Among authors: lai y. Chem Res Toxicol. 2016 Apr 18;29(4):545-63. doi: 10.1021/acs.chemrestox.5b00511. Epub 2016 Mar 8. Chem Res Toxicol. 2016. PMID: 26889774 Review.

8

Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species.

Shen H, Dai J, Liu T, Cheng Y, Chen W, Freeden C, Zhang Y, Humphreys WG, Marathe P, Lai Y. Shen H, et al. Among authors: lai y. J Pharmacol Exp Ther. 2016 May;357(2):382-93. doi: 10.1124/jpet.116.232066. Epub 2016 Feb 23. J Pharmacol Exp Ther. 2016. PMID: 26907622

9

Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury.

Qiu X, Zhang Y, Liu T, Shen H, Xiao Y, Bourner MJ, Pratt JR, Thompson DC, Marathe P, Humphreys WG, Lai Y. Qiu X, et al. Among authors: lai y. Mol Pharm. 2016 Apr 4;13(4):1206-16. doi: 10.1021/acs.molpharmaceut.5b00659. Epub 2016 Mar 8. Mol Pharm. 2016. PMID: 26910619

10

Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment.

Cheng Y, Freeden C, Zhang Y, Abraham P, Shen H, Wescott D, Humphreys WG, Gan J, Lai Y. Cheng Y, et al. Among authors: lai y. Biopharm Drug Dispos. 2016 Jul;37(5):276-86. doi: 10.1002/bdd.2011. Biopharm Drug Dispos. 2016. PMID: 27059119

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