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Characterization of potent and selective iodonium-class inhibitors of NADPH oxidases.
Lu J, Risbood P, Kane CT Jr, Hossain MT, Anderson L, Hill K, Monks A, Wu Y, Antony S, Juhasz A, Liu H, Jiang G, Harris E, Roy K, Meitzler JL, Konaté M, Doroshow JH. Lu J, et al. Biochem Pharmacol. 2017 Nov 1;143:25-38. doi: 10.1016/j.bcp.2017.07.007. Epub 2017 Jul 11. Biochem Pharmacol. 2017. PMID: 28709950 Free PMC article.
Antiproliferative mechanisms of action of the flavin dehydrogenase inhibitors diphenylene iodonium and di-2-thienyliodonium based on molecular profiling of the NCI-60 human tumor cell panel.
Doroshow JH, Juhasz A, Ge Y, Holbeck S, Lu J, Antony S, Wu Y, Jiang G, Roy K. Doroshow JH, et al. Among authors: lu j. Biochem Pharmacol. 2012 May 1;83(9):1195-207. doi: 10.1016/j.bcp.2012.01.022. Epub 2012 Jan 24. Biochem Pharmacol. 2012. PMID: 22305747 Free PMC article.
Activation of TLR4 is required for the synergistic induction of dual oxidase 2 and dual oxidase A2 by IFN-γ and lipopolysaccharide in human pancreatic cancer cell lines.
Wu Y, Lu J, Antony S, Juhasz A, Liu H, Jiang G, Meitzler JL, Hollingshead M, Haines DC, Butcher D, Roy K, Doroshow JH. Wu Y, et al. Among authors: lu j. J Immunol. 2013 Feb 15;190(4):1859-72. doi: 10.4049/jimmunol.1201725. Epub 2013 Jan 7. J Immunol. 2013. PMID: 23296709 Free PMC article.
Effects of iodonium-class flavin dehydrogenase inhibitors on growth, reactive oxygen production, cell cycle progression, NADPH oxidase 1 levels, and gene expression in human colon cancer cells and xenografts.
Doroshow JH, Gaur S, Markel S, Lu J, van Balgooy J, Synold TW, Xi B, Wu X, Juhasz A. Doroshow JH, et al. Among authors: lu j. Free Radic Biol Med. 2013 Apr;57:162-75. doi: 10.1016/j.freeradbiomed.2013.01.002. Epub 2013 Jan 11. Free Radic Biol Med. 2013. PMID: 23314043 Free PMC article.
NADPH oxidases and cancer.
Roy K, Wu Y, Meitzler JL, Juhasz A, Liu H, Jiang G, Lu J, Antony S, Doroshow JH. Roy K, et al. Among authors: lu j. Clin Sci (Lond). 2015 Jun;128(12):863-75. doi: 10.1042/CS20140542. Clin Sci (Lond). 2015. PMID: 25818486 Review.
Dual oxidase 2 and pancreatic adenocarcinoma: IFN-γ-mediated dual oxidase 2 overexpression results in H2O2-induced, ERK-associated up-regulation of HIF-1α and VEGF-A.
Wu Y, Meitzler JL, Antony S, Juhasz A, Lu J, Jiang G, Liu H, Hollingshead M, Haines DC, Butcher D, Panter MS, Roy K, Doroshow JH. Wu Y, et al. Among authors: lu j. Oncotarget. 2016 Oct 18;7(42):68412-68433. doi: 10.18632/oncotarget.12032. Oncotarget. 2016. PMID: 27637085 Free PMC article.
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