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An antipsychotic drug exerts anti-prion effects by altering the localization of the cellular prion protein.
Stincardini C, Massignan T, Biggi S, Elezgarai SR, Sangiovanni V, Vanni I, Pancher M, Adami V, Moreno J, Stravalaci M, Maietta G, Gobbi M, Negro A, Requena JR, Castilla J, Nonno R, Biasini E. Stincardini C, et al. Among authors: vanni i. PLoS One. 2017 Aug 7;12(8):e0182589. doi: 10.1371/journal.pone.0182589. eCollection 2017. PLoS One. 2017. PMID: 28787011 Free PMC article.
In vitro replication highlights the mutability of prions.
Vanni I, Di Bari MA, Pirisinu L, D'Agostino C, Agrimi U, Nonno R. Vanni I, et al. Prion. 2014 Jan-Feb;8(1):154-60. doi: 10.4161/pri.28468. Epub 2014 Mar 11. Prion. 2014. PMID: 24618479 Free PMC article.
A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.
Massignan T, Cimini S, Stincardini C, Cerovic M, Vanni I, Elezgarai SR, Moreno J, Stravalaci M, Negro A, Sangiovanni V, Restelli E, Riccardi G, Gobbi M, Castilla J, Borsello T, Nonno R, Biasini E. Massignan T, et al. Among authors: vanni i. Sci Rep. 2016 Mar 15;6:23180. doi: 10.1038/srep23180. Sci Rep. 2016. PMID: 26976106 Free PMC article.
Isolation of a Defective Prion Mutant from Natural Scrapie.
Vanni I, Migliore S, Cosseddu GM, Di Bari MA, Pirisinu L, D'Agostino C, Riccardi G, Agrimi U, Nonno R. Vanni I, et al. PLoS Pathog. 2016 Nov 23;12(11):e1006016. doi: 10.1371/journal.ppat.1006016. eCollection 2016 Nov. PLoS Pathog. 2016. PMID: 27880822 Free PMC article.
Cofactors influence the biological properties of infectious recombinant prions.
Fernández-Borges N, Di Bari MA, Eraña H, Sánchez-Martín M, Pirisinu L, Parra B, Elezgarai SR, Vanni I, López-Moreno R, Vaccari G, Venegas V, Charco JM, Gil D, Harrathi C, D'Agostino C, Agrimi U, Mayoral T, Requena JR, Nonno R, Castilla J. Fernández-Borges N, et al. Among authors: vanni i. Acta Neuropathol. 2018 Feb;135(2):179-199. doi: 10.1007/s00401-017-1782-y. Epub 2017 Nov 1. Acta Neuropathol. 2018. PMID: 29094186
Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies.
Eraña H, Charco JM, Di Bari MA, Díaz-Domínguez CM, López-Moreno R, Vidal E, González-Miranda E, Pérez-Castro MA, García-Martínez S, Bravo S, Fernández-Borges N, Geijo M, D'Agostino C, Garrido J, Bian J, König A, Uluca-Yazgi B, Sabate R, Khaychuk V, Vanni I, Telling GC, Heise H, Nonno R, Requena JR, Castilla J. Eraña H, et al. Among authors: vanni i. PLoS Pathog. 2019 Oct 23;15(10):e1008117. doi: 10.1371/journal.ppat.1008117. eCollection 2019 Oct. PLoS Pathog. 2019. PMID: 31644574 Free PMC article.
A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants.
Pirisinu L, Di Bari MA, D'Agostino C, Vanni I, Riccardi G, Marcon S, Vaccari G, Chiappini B, Benestad SL, Agrimi U, Nonno R. Pirisinu L, et al. Among authors: vanni i. PLoS Pathog. 2022 Jun 22;18(6):e1010646. doi: 10.1371/journal.ppat.1010646. eCollection 2022 Jun. PLoS Pathog. 2022. PMID: 35731839 Free PMC article.
76 results