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Page 1
Hsp90 activator Aha1 drives production of pathological tau aggregates.
Shelton LB, Baker JD, Zheng D, Sullivan LE, Solanki PK, Webster JM, Sun Z, Sabbagh JJ, Nordhues BA, Koren J 3rd, Ghosh S, Blagg BSJ, Blair LJ, Dickey CA. Shelton LB, et al. Among authors: sabbagh jj. Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9707-9712. doi: 10.1073/pnas.1707039114. Epub 2017 Aug 21. Proc Natl Acad Sci U S A. 2017. PMID: 28827321 Free PMC article.
Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease.
Blair LJ, Sabbagh JJ, Dickey CA. Blair LJ, et al. Among authors: sabbagh jj. Expert Opin Ther Targets. 2014 Oct;18(10):1219-32. doi: 10.1517/14728222.2014.943185. Epub 2014 Jul 29. Expert Opin Ther Targets. 2014. PMID: 25069659 Free PMC article. Review.
Cellular factors modulating the mechanism of tau protein aggregation.
Fontaine SN, Sabbagh JJ, Baker J, Martinez-Licha CR, Darling A, Dickey CA. Fontaine SN, et al. Among authors: sabbagh jj. Cell Mol Life Sci. 2015 May;72(10):1863-79. doi: 10.1007/s00018-015-1839-9. Epub 2015 Feb 11. Cell Mol Life Sci. 2015. PMID: 25666877 Free PMC article. Review.
DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.
Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM Jr, Dickey CA. Fontaine SN, et al. Among authors: sabbagh jj. EMBO J. 2016 Jul 15;35(14):1537-49. doi: 10.15252/embj.201593489. Epub 2016 Jun 3. EMBO J. 2016. PMID: 27261198 Free PMC article.
Human cyclophilin 40 unravels neurotoxic amyloids.
Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, Zweckstetter M, Dickey CA, Koren J 3rd, Blair LJ. Baker JD, et al. Among authors: sabbagh jj. PLoS Biol. 2017 Jun 27;15(6):e2001336. doi: 10.1371/journal.pbio.2001336. eCollection 2017 Jun. PLoS Biol. 2017. PMID: 28654636 Free PMC article.
Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.
Fontaine SN, Rauch JN, Nordhues BA, Assimon VA, Stothert AR, Jinwal UK, Sabbagh JJ, Chang L, Stevens SM Jr, Zuiderweg ER, Gestwicki JE, Dickey CA. Fontaine SN, et al. Among authors: sabbagh jj. J Biol Chem. 2015 May 22;290(21):13115-27. doi: 10.1074/jbc.M115.637595. Epub 2015 Apr 11. J Biol Chem. 2015. PMID: 25864199 Free PMC article.
28 results