Lücking U - Search Results

1

Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer.

Lücking U, Scholz A, Lienau P, Siemeister G, Kosemund D, Bohlmann R, Briem H, Terebesi I, Meyer K, Prelle K, Denner K, Bömer U, Schäfer M, Eis K, Valencia R, Ince S, von Nussbaum F, Mumberg D, Ziegelbauer K, Klebl B, Choidas A, Nussbaumer P, Baumann M, Schultz-Fademrecht C, Rühter G, Eickhoff J, Brands M. Lücking U, et al. ChemMedChem. 2017 Nov 8;12(21):1776-1793. doi: 10.1002/cmdc.201700447. Epub 2017 Oct 16. ChemMedChem. 2017. PMID: 28961375 Free PMC article.

2

From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors.

Jautelat R, Brumby T, Schäfer M, Briem H, Eisenbrand G, Schwahn S, Krüger M, Lücking U, Prien O, Siemeister G. Jautelat R, et al. Among authors: lucking u. Chembiochem. 2005 Mar;6(3):531-40. doi: 10.1002/cbic.200400108. Chembiochem. 2005. PMID: 15742375 No abstract available.

3

Macrocyclic aminopyrimidines as multitarget CDK and VEGF-R inhibitors with potent antiproliferative activities.

Lücking U, Siemeister G, Schäfer M, Briem H, Krüger M, Lienau P, Jautelat R. Lücking U, et al. ChemMedChem. 2007 Jan;2(1):63-77. doi: 10.1002/cmdc.200600199. ChemMedChem. 2007. PMID: 17131463

4

Off-target decoding of a multitarget kinase inhibitor by chemical proteomics.

Missner E, Bahr I, Badock V, Lücking U, Siemeister G, Donner P. Missner E, et al. Among authors: lucking u. Chembiochem. 2009 May 4;10(7):1163-74. doi: 10.1002/cbic.200800796. Chembiochem. 2009. PMID: 19350611

5

BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application.

Siemeister G, Lücking U, Wengner AM, Lienau P, Steinke W, Schatz C, Mumberg D, Ziegelbauer K. Siemeister G, et al. Among authors: lucking u. Mol Cancer Ther. 2012 Oct;11(10):2265-73. doi: 10.1158/1535-7163.MCT-12-0286. Epub 2012 Jul 19. Mol Cancer Ther. 2012. PMID: 22821149

6

The lab oddity prevails: discovery of pan-CDK inhibitor (R)-S-cyclopropyl-S-(4-{[4-{[(1R,2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide (BAY 1000394) for the treatment of cancer.

Lücking U, Jautelat R, Krüger M, Brumby T, Lienau P, Schäfer M, Briem H, Schulze J, Hillisch A, Reichel A, Wengner AM, Siemeister G. Lücking U, et al. ChemMedChem. 2013 Jul;8(7):1067-85. doi: 10.1002/cmdc.201300096. Epub 2013 May 13. ChemMedChem. 2013. PMID: 23671017

7

BAY 1024767 blocks androgen receptor mutants found in castration-resistant prostate cancer patients.

Sugawara T, Lejeune P, Köhr S, Neuhaus R, Faus H, Gelato KA, Busemann M, Cleve A, Lücking U, von Nussbaum F, Brands M, Mumberg D, Jung K, Stephan C, Haendler B. Sugawara T, et al. Among authors: lucking u. Oncotarget. 2016 Feb 2;7(5):6015-28. doi: 10.18632/oncotarget.6864. Oncotarget. 2016. PMID: 26760770 Free PMC article.

8

Conformational Adaption May Explain the Slow Dissociation Kinetics of Roniciclib (BAY 1000394), a Type I CDK Inhibitor with Kinetic Selectivity for CDK2 and CDK9.

Ayaz P, Andres D, Kwiatkowski DA, Kolbe CC, Lienau P, Siemeister G, Lücking U, Stegmann CM. Ayaz P, et al. Among authors: lucking u. ACS Chem Biol. 2016 Jun 17;11(6):1710-9. doi: 10.1021/acschembio.6b00074. Epub 2016 Apr 19. ACS Chem Biol. 2016. PMID: 27090615 Free article.

9

Novel Pieces for the Emerging Picture of Sulfoximines in Drug Discovery: Synthesis and Evaluation of Sulfoximine Analogues of Marketed Drugs and Advanced Clinical Candidates.

Sirvent JA, Lücking U. Sirvent JA, et al. Among authors: lucking u. ChemMedChem. 2017 Apr 6;12(7):487-501. doi: 10.1002/cmdc.201700044. Epub 2017 Mar 22. ChemMedChem. 2017. PMID: 28221724 Free PMC article.

10

A New, Practical One-Pot Synthesis of Unprotected Sulfonimidamides by Transfer of Electrophilic NH to Sulfinamides.

Izzo F, Schäfer M, Stockman R, Lücking U. Izzo F, et al. Among authors: lucking u. Chemistry. 2017 Oct 26;23(60):15189-15193. doi: 10.1002/chem.201703272. Epub 2017 Oct 9. Chemistry. 2017. PMID: 28833686 Free PMC article.

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