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Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target.
Brzezinka K, Nevedomskaya E, Lesche R, Haegebarth A, Ter Laak A, Fernández-Montalván AE, Eberspaecher U, Werbeck ND, Moenning U, Siegel S, Haendler B, Eheim AL, Stresemann C. Brzezinka K, et al. Among authors: lesche r. Cancers (Basel). 2020 Jan 14;12(1):201. doi: 10.3390/cancers12010201. Cancers (Basel). 2020. PMID: 31947537 Free PMC article.
Preclinical Efficacy of the Novel Monocarboxylate Transporter 1 Inhibitor BAY-8002 and Associated Markers of Resistance.
Quanz M, Bender E, Kopitz C, Grünewald S, Schlicker A, Schwede W, Eheim A, Toschi L, Neuhaus R, Richter C, Toedling J, Merz C, Lesche R, Kamburov A, Siebeneicher H, Bauser M, Hägebarth A. Quanz M, et al. Among authors: lesche r. Mol Cancer Ther. 2018 Nov;17(11):2285-2296. doi: 10.1158/1535-7163.MCT-17-1253. Epub 2018 Aug 16. Mol Cancer Ther. 2018. PMID: 30115664
Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis.
Regan JL, Schumacher D, Staudte S, Steffen A, Lesche R, Toedling J, Jourdan T, Haybaeck J, Golob-Schwarzl N, Mumberg D, Henderson D, Győrffy B, Regenbrecht CRA, Keilholz U, Schäfer R, Lange M. Regan JL, et al. Among authors: lesche r. iScience. 2022 May 31;25(7):104498. doi: 10.1016/j.isci.2022.104498. eCollection 2022 Jul 15. iScience. 2022. PMID: 35720265 Free PMC article.
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
Christian S, Merz C, Evans L, Gradl S, Seidel H, Friberg A, Eheim A, Lejeune P, Brzezinka K, Zimmermann K, Ferrara S, Meyer H, Lesche R, Stoeckigt D, Bauser M, Haegebarth A, Sykes DB, Scadden DT, Losman JA, Janzer A. Christian S, et al. Among authors: lesche r. Leukemia. 2019 Oct;33(10):2403-2415. doi: 10.1038/s41375-019-0461-5. Epub 2019 Apr 2. Leukemia. 2019. PMID: 30940908
RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence.
Regan JL, Schumacher D, Staudte S, Steffen A, Lesche R, Toedling J, Jourdan T, Haybaeck J, Mumberg D, Henderson D, Győrffy B, Regenbrecht CRA, Keilholz U, Schäfer R, Lange M. Regan JL, et al. Among authors: lesche r. iScience. 2021 May 24;24(6):102618. doi: 10.1016/j.isci.2021.102618. eCollection 2021 Jun 25. iScience. 2021. PMID: 34142064 Free PMC article.
74 results