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Transient Changes in Hepatic Physiology That Alter Bilirubin and Bile Acid Transport May Explain Elevations in Liver Chemistries Observed in Clinical Trials of GGF2 (Cimaglermin Alfa).
Mosedale M, Button D, Jackson JP, Freeman KM, Brouwer KR, Caggiano AO, Eisen A, Iaci JF, Parry TJ, Stanulis R, Srinivas M, Watkins PB. Mosedale M, et al. Among authors: iaci jf. Toxicol Sci. 2018 Feb 1;161(2):401-411. doi: 10.1093/toxsci/kfx222. Toxicol Sci. 2018. PMID: 29069498
Effects of neuregulin GGF2 (cimaglermin alfa) dose and treatment frequency on left ventricular function in rats following myocardial infarction.
Parry TJ, Ganguly A, Troy EL, Luis Guerrero J, Iaci JF, Srinivas M, Vecchione AM, Button DC, Hackett CS, Zolty R, Sawyer DB, Caggiano AO. Parry TJ, et al. Among authors: iaci jf. Eur J Pharmacol. 2017 Feb 5;796:76-89. doi: 10.1016/j.ejphar.2016.12.024. Epub 2016 Dec 16. Eur J Pharmacol. 2017. PMID: 27993643 Free article.
A Phase I, Single Ascending Dose Study of Cimaglermin Alfa (Neuregulin 1β3) in Patients With Systolic Dysfunction and Heart Failure.
Lenihan DJ, Anderson SA, Lenneman CG, Brittain E, Muldowney JAS 3rd, Mendes L, Zhao PZ, Iaci J, Frohwein S, Zolty R, Eisen A, Sawyer DB, Caggiano AO. Lenihan DJ, et al. JACC Basic Transl Sci. 2016 Dec 26;1(7):576-586. doi: 10.1016/j.jacbts.2016.09.005. eCollection 2016 Dec. JACC Basic Transl Sci. 2016. PMID: 30167542 Free PMC article. Review.
Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1β improves left ventricular function, gene and protein expression in rats after myocardial infarction.
Hill MF, Patel AV, Murphy A, Smith HM, Galindo CL, Pentassuglia L, Peng X, Lenneman CG, Odiete O, Friedman DB, Kronenberg MW, Zheng S, Zhao Z, Song Y, Harrell FE Jr, Srinivas M, Ganguly A, Iaci J, Parry TJ, Caggiano AO, Sawyer DB. Hill MF, et al. PLoS One. 2013;8(2):e55741. doi: 10.1371/journal.pone.0055741. Epub 2013 Feb 21. PLoS One. 2013. PMID: 23437060 Free PMC article.
15 results