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Ineffective erythropoiesis in beta-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin.
Gardenghi S, Marongiu MF, Ramos P, Guy E, Breda L, Chadburn A, Liu Y, Amariglio N, Rechavi G, Rachmilewitz EA, Breuer W, Cabantchik ZI, Wrighting DM, Andrews NC, de Sousa M, Giardina PJ, Grady RW, Rivella S. Gardenghi S, et al. Among authors: ramos p. Blood. 2007 Jun 1;109(11):5027-35. doi: 10.1182/blood-2006-09-048868. Epub 2007 Feb 13. Blood. 2007. PMID: 17299088 Free PMC article.
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia.
Libani IV, Guy EC, Melchiori L, Schiro R, Ramos P, Breda L, Scholzen T, Chadburn A, Liu Y, Kernbach M, Baron-Lühr B, Porotto M, de Sousa M, Rachmilewitz EA, Hood JD, Cappellini MD, Giardina PJ, Grady RW, Gerdes J, Rivella S. Libani IV, et al. Among authors: ramos p. Blood. 2008 Aug 1;112(3):875-85. doi: 10.1182/blood-2007-12-126938. Epub 2008 May 14. Blood. 2008. PMID: 18480424 Free PMC article.
Hepcidin and Hfe in iron overload in beta-thalassemia.
Gardenghi S, Ramos P, Follenzi A, Rao N, Rachmilewitz EA, Giardina PJ, Grady RW, Rivella S. Gardenghi S, et al. Among authors: ramos p. Ann N Y Acad Sci. 2010 Aug;1202:221-5. doi: 10.1111/j.1749-6632.2010.05595.x. Ann N Y Acad Sci. 2010. PMID: 20712796 Free PMC article. Review.
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice.
Gardenghi S, Ramos P, Marongiu MF, Melchiori L, Breda L, Guy E, Muirhead K, Rao N, Roy CN, Andrews NC, Nemeth E, Follenzi A, An X, Mohandas N, Ginzburg Y, Rachmilewitz EA, Giardina PJ, Grady RW, Rivella S. Gardenghi S, et al. Among authors: ramos p. J Clin Invest. 2010 Dec;120(12):4466-77. doi: 10.1172/JCI41717. Epub 2010 Nov 22. J Clin Invest. 2010. PMID: 21099112 Free PMC article.
Protective role of calreticulin in HFE hemochromatosis.
Pinto JP, Ramos P, de Almeida SF, Oliveira S, Breda L, Michalak M, Porto G, Rivella S, de Sousa M. Pinto JP, et al. Among authors: ramos p. Free Radic Biol Med. 2008 Jan 1;44(1):99-108. doi: 10.1016/j.freeradbiomed.2007.09.014. Epub 2007 Oct 4. Free Radic Biol Med. 2008. PMID: 18045552
1,023 results