Priming of endothelial colony-forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition orchestrated by NOTCH signaling.
Shafiee A, Patel J, Wong HY, Donovan P, Hutmacher DW, Fisk NM, Khosrotehrani K.
Shafiee A, et al. Among authors: patel j.
FASEB J. 2017 Feb;31(2):610-624. doi: 10.1096/fj.201600937. Epub 2016 Oct 24.
FASEB J. 2017.
PMID: 28045376
The collective results showed that primed ECFCs survive better and undergo a mesenchymal transition that is dependent on NOTCH signaling, resulting in significantly increased vasculogenic potential.-Shafiee, A., Patel, J., Wong, H. Y., Donovan, P., Hutmacher, D. W., …
The collective results showed that primed ECFCs survive better and undergo a mesenchymal transition that is dependent on NOTCH signaling, re …