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A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models.
Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. Zhou Y, et al. Among authors: johnson ac. Science. 2017 Dec 8;358(6368):1332-1336. doi: 10.1126/science.aal4178. Science. 2017. PMID: 29217578 Free PMC article.
Early development of podocyte injury independently of hyperglycemia and elevations in arterial pressure in nondiabetic obese Dahl SS leptin receptor mutant rats.
McPherson KC, Taylor L, Johnson AC, Didion SP, Geurts AM, Garrett MR, Williams JM. McPherson KC, et al. Among authors: johnson ac. Am J Physiol Renal Physiol. 2016 Oct 1;311(4):F793-F804. doi: 10.1152/ajprenal.00590.2015. Epub 2016 Jul 27. Am J Physiol Renal Physiol. 2016. PMID: 27465994 Free PMC article.
Altered renal hemodynamics is associated with glomerular lipid accumulation in obese Dahl salt-sensitive leptin receptor mutant rats.
McPherson KC, Shields CA, Poudel B, Johnson AC, Taylor L, Stubbs C, Nichols A, Cornelius DC, Garrett MR, Williams JM. McPherson KC, et al. Among authors: johnson ac. Am J Physiol Renal Physiol. 2020 Apr 1;318(4):F911-F921. doi: 10.1152/ajprenal.00438.2019. Epub 2020 Feb 18. Am J Physiol Renal Physiol. 2020. PMID: 32068459 Free PMC article.
612 results