Kuca K - Search Results

1

In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley?

Soukup O, Korabecny J, Malinak D, Nepovimova E, Pham NL, Musilek K, Hrabinova M, Hepnarova V, Dolezal R, Pavek P, Jost P, Kobrlova T, Jankockova J, Gorecki L, Psotka M, Nguyen TD, Box K, Outhwaite B, Ceckova M, Sorf A, Jun D, Kuca K. Soukup O, et al. Among authors: kuca k. Med Chem. 2018;14(3):281-292. doi: 10.2174/1573406414666180112105657. Med Chem. 2018. PMID: 29332594

2

Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase.

Kuca K, Bielavský J, Cabal J, Kassa J. Kuca K, et al. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3545-7. doi: 10.1016/s0960-894x(03)00751-0. Bioorg Med Chem Lett. 2003. PMID: 14505667

3

A comparison of the ability of a new bispyridinium oxime--1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide and currently used oximes to reactivate nerve agent-inhibited rat brain acetylcholinesterase by in vitro methods.

Kuca K, Kassa J. Kuca K, et al. J Enzyme Inhib Med Chem. 2003 Dec;18(6):529-35. doi: 10.1080/14756360310001605552. J Enzyme Inhib Med Chem. 2003. PMID: 15008517 Free article.

4

Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes.

Kuca K, Patocka J, Cabal J, Jun D. Kuca K, et al. Neurotox Res. 2004;6(7-8):565-70. doi: 10.1007/BF03033452. Neurotox Res. 2004. PMID: 15639788

5

Acetylcholinesterase and butyrylcholinesterase--important enzymes of human body.

Patocka J, Kuca K, Jun D. Patocka J, et al. Among authors: kuca k. Acta Medica (Hradec Kralove). 2004;47(4):215-28. Acta Medica (Hradec Kralove). 2004. PMID: 15841900 Review.

6

A comparison of the potency of newly developed oximes (K005, K027, K033, K048) and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited rat brain acetylcholinesterase by in vitro methods.

Kuca K, Cabal J, Kassa J. Kuca K, et al. J Toxicol Environ Health A. 2005 Apr 23;68(8):677-86. doi: 10.1080/15287390590921784. J Toxicol Environ Health A. 2005. PMID: 15901095

7

Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents.

Kim TH, Kuca K, Jun D, Jung YS. Kim TH, et al. Among authors: kuca k. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2914-7. doi: 10.1016/j.bmcl.2005.03.060. Epub 2005 Apr 21. Bioorg Med Chem Lett. 2005. PMID: 15911280

8

Comparison of in vitro potency of oximes (pralidoxime, obidoxime, HI-6) to reactivate sarin-inhibited acetylcholinesterase in various parts of pig brain.

Kuca K, Cabal J, Kassa J, Jun D, Hrabinová M. Kuca K, et al. J Appl Toxicol. 2005 Jul-Aug;25(4):271-6. doi: 10.1002/jat.1053. J Appl Toxicol. 2005. PMID: 16021679

9

In vitro reactivation potency of some acetylcholinesterase reactivators against sarin- and cyclosarin-induced inhibitions.

Kuca K, Cabal J, Jun D, Kassa J, Bartosová L, Kunesová G. Kuca K, et al. J Appl Toxicol. 2005 Jul-Aug;25(4):296-300. doi: 10.1002/jat.1065. J Appl Toxicol. 2005. PMID: 16025528

10

Effective bisquaternary reactivators of tabun-inhibited AChE.

Kuca K, Cabal J, Musilek K, Jun D, Bajgar J. Kuca K, et al. J Appl Toxicol. 2005 Nov-Dec;25(6):491-5. doi: 10.1002/jat.1084. J Appl Toxicol. 2005. PMID: 16092078

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